ID A0A3P8XJE8_ESOLU Unreviewed; 2256 AA.
AC A0A3P8XJE8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Retinal-specific ATP-binding cassette transporter {ECO:0000313|Ensembl:ENSELUP00000004691.2};
GN Name=ABCA4 {ECO:0000313|Ensembl:ENSELUP00000004691.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004691.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000004691.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000004691.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8010.ENSELUP00000004691; -.
DR Ensembl; ENSELUT00000011941.2; ENSELUP00000004691.2; ENSELUG00000005840.2.
DR GeneTree; ENSGT00940000155624; -.
DR Proteomes; UP000265140; LG03.
DR Bgee; ENSELUG00000005840; Expressed in camera-type eye and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF190; RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 823..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1334..1355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1642..1664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1671..1688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1694..1711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1723..1741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1753..1778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1841..1863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 922..1153
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1900..2132
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 2217..2256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2217..2240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2242..2256
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2256 AA; 254444 MW; 5DE046D90416C845 CRC64;
MNAGSQIRLL LWKNWTLRKR QKVRFLVEIL WPLVLFIGLV WLRKANPLYK QHECHFPNKA
MPSTGILPWI QGIFCNANNP CFRHATRAEG PGLVSNYNNC ILARFWADTN ELLFDEPEFR
QLGRLWDDMG IMNNFMDTIC HTPEKISGRG LKIESILKDD EMLTAFLLRD TGLPESVVDN
LIKSQVRPEQ FAHGVPDLQL KDIACSLTLL ERFIIFPSRM AVYGVRNALC ALSQQRLQKI
EDMLYANVDF FKIFRLVWSL SLSVCLYICL SCQLSPFSIT RPHNHSSFSA VYPLFQTGGP
NSFSQLMSTV SALFCGYPEG EGSRVLSFNW YEDNNYKVFL GVNGSKNQDY VYDKTTTPFC
NDLMQTLESN PVTKIVWRSV KPMVMGRVLY APDSPAVRQI LKSANTTFEE LDRLLTMAKA
WEEVGPQLWR FFNNGIQMNM IRDTIRNPTV TELIDKSLED TEFSSKDILN FLYNGPEEDR
DETMPKFDWR NIFNLMDQVI RMFNQYAQCI SLDKFTPHTD EDQLTHQALF LLEENKFWAG
LVFLDMYPWT TSVPPHVKYK IRMDIDQVER TNKIKDRYWD PGPRADPVED LRYIWGGFAY
LQDMVEHGIL KIHTGNDWPL GVYVQQMPYP CYVDDLFMLT LNRCFPMFMV LAWIYSVSMI
VKSIVLEKEL RLKETLKAMG VTNGVIWYTW FIDSFIMMTA STALLTAIIM AGKVLNYSNP
FVVFLFLLTF TTATIMQCFL LSVFFNKANL AAACSGIVYF TLYLPHILCV AWQDRITRNT
KIAASLLSPV AFGFGTEYLS RYEEQGLGLQ WDNIGTSPLE GDAYSFFTSI GMMVFDAVLY
GFLAWYLDNV FPGQYGIGRP FYFPFQPSYW QRPEGPDSLV HHKTGSLYTA RHRSSSSLHA
CPSPAEGQLL FEPEPAGLTV GVEIQDLVKV FPGRSRPAVD HLSITFYEGQ ITSFLGHNGA
GKTTTMSILT GMYPPTSGTA FINGRDIRTD MDIIRTSMGM CPQYNILFKH LTVEEHILFY
SLLKGTSLTG AQQEVEAMLE DLGLPHKRDD EAQNLSGGMQ RKLSVAMAFV GGSKIVILDE
PTSGVDPYSR RSIWDLLLKY RTGRTVILST HHMDEADLLS DRVAIISKGQ LHCCGSPLFL
KNCFGVGFYL TLVRRMKDIR KKENECDCAS EFSCKIILTP LLGNVDSITA LIHHHVPDAK
LIEAIGQELT FLLPNKGFKH RAYASLFREL EETLGDMGLS SFGISDTSLE EIFLKVTADG
EAAANAKAPG NLYPHCPTLK ADELKQANGT RLRAEDCSDG KGSRQIKGAS LVMKQFLALL
VKRFHHATRS LKDFLAQIVL PASFVLIALV FTMIVPPFGE YPALTLSPWM YGQQFTFFSN
ERQGNYQMTR FAKALLNPPG LGTRCMSGVD LKNLPCENET LDWETPEVSP IVTNILQSPA
WNPLDPSPSC QCSTNKKLTM LPICPVGAGG LPPKQRKEAT GDILLDLTER NISDYLVKTY
PSLIRRSLKS KYWVNEQRYG GLSVGGQLPI LDVSPKQIQD VASQLMKMLN VTGGPNTKQS
LREIGPFLRY MESEYNVKVW YNNKGWHAMV AFMNVANNAI LRAYLPRNAN PMEYGITAVN
HPLNLTKEQL SEVTVLKTSV DAVTAICVIF AMSFIPASFV LYLIQERVSK AKHLQFVSGV
SPLVYWVANF FWDMVNYSLS TAMVVGIFVA FDKKCYTSAA NLPALVLLLL LYGWSVTPMM
YPMSYVFNIP STAYVSLSCI NLFIGINSSA LTFILELFEN NRSLLEFNEW LKKGLLVFPH
FCLGRGLIDM AMNQAVTDVY AHFGEDHAMD PFKWNFVGKN LVFMAVEGFL YFLLNILIQY
RFFLDQWLSD FKGPPPKDED EDVAEERERI YNGGSKSDIL QIRDLCKTYT GRKRPAVDRI
CVGVSSGECF GLLGVNGAGK TTTFKMLTGD ADVSFGEATV AGYSILSEML DVHQNMGYCP
QCDAVDDLLT GREHLFLYAR LRGVPESEIS RVAEWGIQKL GLSEYAGRCA GTYSGGNKRK
LSTAIAMIGC PALVLLDEPT TGMDPHSRRF LWTAIMSVIQ DGRAVVLTSH SMEECEALCT
RLAIMVNGTF KCLGTIQHLK YKFGEGYVVT MKVKAVKAGV PPDLGLAESF MDSSFPGCVQ
REKHYNTLQY EIASSSLARI FQLVVANKDK LNIEDYSVSQ TTLDQVFVNF AKQQAGEDDD
TVPETRAAGS RKETRSVTIR RKVSPIKIKT RRQTRT
//