ID   A0A3P8XK75_ESOLU        Unreviewed;       655 AA.
AC   A0A3P8XK75;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=TIR domain-containing adapter molecule 1 {ECO:0000313|Ensembl:ENSELUP00000004971.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004971.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000004971.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000004971.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8XK75; -.
DR   STRING; 8010.ENSELUP00000004971; -.
DR   Ensembl; ENSELUT00000011431.2; ENSELUP00000004971.2; ENSELUG00000006060.2.
DR   GeneTree; ENSGT00940000163706; -.
DR   InParanoid; A0A3P8XK75; -.
DR   OMA; TRHGWQD; -.
DR   OrthoDB; 4640439at2759; -.
DR   Proteomes; UP000265140; LG19.
DR   Bgee; ENSELUG00000006060; Expressed in ovary and 15 other cell types or tissues.
DR   GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.25.40.780; -; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR046946; TCAM1/2.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR040886; TRIF_N.
DR   PANTHER; PTHR47230; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR   PANTHER; PTHR47230:SF1; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   Pfam; PF17798; TRIF-NTD; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          391..552
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          273..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   655 AA;  72981 MW;  55E4D70CDCB8850B CRC64;
     MTSEMDRKAH TEEEHHGGTG LVDVLKILTK VPYERKLSLN FTLGVSLAEE MVRAISLISL
     GKRSEALEKL QALGDNLIAN YLAEKVRMCG VKLENLSTVS FQESNVDTLV DLARMFKVLA
     EERLCDQTLR DLAYQTALAA CKNKNCVKER SKVEYLYMEL SDEAKKVCGP QIEYTVKGTS
     PKDFSGLCSN QPLVEGRTIL GFLDQTGSGQ SLPSSLREDS TIYSYPSHLE ISVSETIGLK
     PSNLPLQPPS PMSLEPVPSQ NQGVLKYFSR VMSRDKSPTQ NEPQPVKVEM DSEKSFAPSC
     ENESVSEDMR VVSLSPGSST PAHIKIGNPM SLNGHDKVCP TKNLVPPSNT SRPASHPTTL
     ENSSTLGVPL TEQVSASAAL IPPLLEEEEE DFFSFVVLHA QEDVAMAEML TEKLEATGVG
     KGATFQEFAI PGKNLLMCVE DAINNSAFTI LLLTSNFNSR LLEVEASSAL MNAIQNRHKY
     NTVIPFLPRE NCMPNEKMPS VLRIYIPLRE DKTFEKKAKR AMTPAKIAMQ RQLWLTEQAV
     RAEVKRRERL QMEEKLRGDL IREQFVNQQV EMMRKHLSQQ QVNELITPAG GHFAAQGLEN
     QQFNLTNMRL QKNGWSHPQG NIRIENARYI MIGDNSAMTV GIGRDSSEEE DDDRC
//