ID A0A3P8XK75_ESOLU Unreviewed; 655 AA.
AC A0A3P8XK75;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=TIR domain-containing adapter molecule 1 {ECO:0000313|Ensembl:ENSELUP00000004971.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004971.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000004971.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000004971.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8XK75; -.
DR STRING; 8010.ENSELUP00000004971; -.
DR Ensembl; ENSELUT00000011431.2; ENSELUP00000004971.2; ENSELUG00000006060.2.
DR GeneTree; ENSGT00940000163706; -.
DR InParanoid; A0A3P8XK75; -.
DR OMA; TRHGWQD; -.
DR OrthoDB; 4640439at2759; -.
DR Proteomes; UP000265140; LG19.
DR Bgee; ENSELUG00000006060; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.40.780; -; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR046946; TCAM1/2.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR040886; TRIF_N.
DR PANTHER; PTHR47230; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR PANTHER; PTHR47230:SF1; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR Pfam; PF13676; TIR_2; 1.
DR Pfam; PF17798; TRIF-NTD; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 391..552
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 273..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 72981 MW; 55E4D70CDCB8850B CRC64;
MTSEMDRKAH TEEEHHGGTG LVDVLKILTK VPYERKLSLN FTLGVSLAEE MVRAISLISL
GKRSEALEKL QALGDNLIAN YLAEKVRMCG VKLENLSTVS FQESNVDTLV DLARMFKVLA
EERLCDQTLR DLAYQTALAA CKNKNCVKER SKVEYLYMEL SDEAKKVCGP QIEYTVKGTS
PKDFSGLCSN QPLVEGRTIL GFLDQTGSGQ SLPSSLREDS TIYSYPSHLE ISVSETIGLK
PSNLPLQPPS PMSLEPVPSQ NQGVLKYFSR VMSRDKSPTQ NEPQPVKVEM DSEKSFAPSC
ENESVSEDMR VVSLSPGSST PAHIKIGNPM SLNGHDKVCP TKNLVPPSNT SRPASHPTTL
ENSSTLGVPL TEQVSASAAL IPPLLEEEEE DFFSFVVLHA QEDVAMAEML TEKLEATGVG
KGATFQEFAI PGKNLLMCVE DAINNSAFTI LLLTSNFNSR LLEVEASSAL MNAIQNRHKY
NTVIPFLPRE NCMPNEKMPS VLRIYIPLRE DKTFEKKAKR AMTPAKIAMQ RQLWLTEQAV
RAEVKRRERL QMEEKLRGDL IREQFVNQQV EMMRKHLSQQ QVNELITPAG GHFAAQGLEN
QQFNLTNMRL QKNGWSHPQG NIRIENARYI MIGDNSAMTV GIGRDSSEEE DDDRC
//