ID A0A3P8XKA9_ESOLU Unreviewed; 553 AA.
AC A0A3P8XKA9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004985.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000004985.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000004985.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_010871291.1; XM_010872989.2.
DR AlphaFoldDB; A0A3P8XKA9; -.
DR Ensembl; ENSELUT00000011415.2; ENSELUP00000004985.1; ENSELUG00000006083.2.
DR GeneID; 105012279; -.
DR GeneTree; ENSGT00940000153882; -.
DR OrthoDB; 2916807at2759; -.
DR Proteomes; UP000265140; LG09.
DR Bgee; ENSELUG00000006083; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00055; EGF_Lam; 2.
DR CDD; cd03579; NTR_netrin-1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF378; NETRIN-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 2.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 2.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 46..283
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 284..339
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 421..550
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 286..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 305..314
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 553 AA; 62553 MW; 1C66D3E0B5AD5D6F CRC64;
MLRILDAVVT VVAVSFVVEG VLGGYGMSMF AAQTSPPDPC YDENGNPRRC IPDFVNSAFG
KEVRASSTCG KTPGRFCVVT EKDDERNRNC HTCDASDPKK YHPPTYLTDL NNPHNLTCWQ
SENYIQYPQN VTLTLSLGKK FEVTYVSLQF CSPRPESMAI FKSMDYGKSW VPFQFYSTQC
RKMYNKPSKA TITKQNEQEA ICTDSHTDMH PLSGGLIAFS TLDGRPSAHD FDNSPVLQDW
VTATDIKVTF SRLHTFGDEN EDDSELARDS YFYAVSDLQV GGRCKCNGHA SRCVKDRDGN
LVCECKHNTA GPECDRCKPF HYDRPWQRAT AREANECVAC NCNLHARRCR FNMELYKLSG
RKSGGVCLNC RHNTAGRHCH YCKEGFYRDL SKPISHRKAC KEIPVAPPTT TASSTEEPAD
CDSYCKASKG KLKINMKKYC KKDYAVQVHI LKADKAGEWW KFTVNIISVY KQGESRIRRG
DQFLWVRAKD VACKCPKIKP GKKYLLLGND EDSPGQSGVV ADKGSLVIQW RDTWARRLRK
FQQREKKGKC KKA
//
