ID A0A3P8XKU0_ESOLU Unreviewed; 913 AA.
AC A0A3P8XKU0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Scm like with four mbt domains 2 {ECO:0000313|Ensembl:ENSELUP00000005177.2};
GN Name=SFMBT2 {ECO:0000313|Ensembl:ENSELUP00000005177.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000005177.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000005177.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000005177.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3P8XKU0; -.
DR STRING; 8010.ENSELUP00000005177; -.
DR Ensembl; ENSELUT00000011113.2; ENSELUP00000005177.2; ENSELUG00000006232.2.
DR GeneTree; ENSGT00940000158123; -.
DR InParanoid; A0A3P8XKU0; -.
DR OMA; NMSEPFH; -.
DR OrthoDB; 5405166at2759; -.
DR Proteomes; UP000265140; LG23.
DR Bgee; ENSELUG00000006232; Expressed in stomach and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd09581; SAM_Scm-like-4MBT1_2; 1.
DR Gene3D; 2.30.30.140; -; 4.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037604; Scm-like-4MBT1/2_SAM.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF62; SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2; 1.
DR Pfam; PF02820; MBT; 4.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 4.
DR PROSITE; PS51079; MBT; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 41..141
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 156..260
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 270..376
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 384..481
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 840..906
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 102868 MW; EF44FF1155AE1F36 CRC64;
MQSRPQDRPL VLSAGKSNSL TNGREDQVHS DVDSTEEGAY FNWEEYLEET GATAAPHSAF
KHVEISLQSS FQPGMKLEVA NKSSPDTYWV ATIITTCGQL LLLRFSGYGD DRKADFWCDV
MTAELHPVGW CAQNNKTLQP PEDNVYLRKA IKEKYTDWTD FLIQDLTGSR TTPANLLEGP
LRGKNTVDLI VGGSMMEVRD LTDPSLYWAV RVIQNIGGRL CLRYVGLHDD DAHDIWLFYL
DVRLRPLGWA QENCLELRPP GELHGQKSAN EWHDALEAAW SEARRNPLPL EVFKDHADLT
KHSFSAGMKL EMVSPWEPLH ICPVSVTQVY NEHYFQVTVD DLSPEPKPLS LVCHAESLGI
LPVQWCLKNG IGLQRPRGCL SQDFDWADYL KQSGTEAAPD ACFPGAWESR GFAKDMWLEA
VNPIKPAEVC VAQITQVRGR LLWLKLEGLP MPVSECIVDV QSMDIFPVGW CEANAYHLTP
PLKPASQQQK KIAVVQPEKQ LAPPQPAETV PLNLCQPVAM DTGSANGRYC CSRIYVNHRC
FSGPYLNKGR IAELPQAVGP GKCTLVLKEV LSMLINAAYK PGRVLRELQE VEDQQWDCHE
ETLKAKYKGK TYRSSIRIVR LAEQIPDFCR KVCAKLQCCP NLFSPVQVTD KCPENCSIQT
KTKYSWCVRA RTNTVNFFKS YYYGKKRKLS KPCGAEESLE ATPTRRRKKR KAIFVQKKRR
SSTVDLTPAG SPQNSDEDDD EDYLMMQSGS EEGTGSEPRD DRTDTSSVET GSTRPRRAVT
LRRATHTGIV TDGLEVPDNR RRSTRSLSYN QGNKYHPPKR EEMQVECGEE EGRLVLERNP
LEWSVQDVVT FITSTDCAAL ASIFQEQDID GQALLLLTLP TVQECMELKL GPAIKLCHQI
ERVKVAFYAQ YAN
//
