ID A0A3P8XKV0_ESOLU Unreviewed; 173 AA.
AC A0A3P8XKV0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Dickkopf-related protein 3 {ECO:0000313|Ensembl:ENSELUP00000004289.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004289.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000004289.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000004289.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the dickkopf family.
CC {ECO:0000256|ARBA:ARBA00010842}.
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DR RefSeq; XP_010902697.1; XM_010904395.2.
DR RefSeq; XP_019901794.1; XM_020046235.1.
DR RefSeq; XP_019901795.1; XM_020046236.1.
DR AlphaFoldDB; A0A3P8XKV0; -.
DR Ensembl; ENSELUT00000012596.2; ENSELUP00000004289.2; ENSELUG00000005455.2.
DR GeneID; 105030498; -.
DR KEGG; els:105030498; -.
DR GeneTree; ENSGT00390000000221; -.
DR InParanoid; A0A3P8XKV0; -.
DR OMA; GPSMCCA; -.
DR OrthoDB; 3058712at2759; -.
DR Proteomes; UP000265140; LG05.
DR Bgee; ENSELUG00000005455; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR048500; DIKK1/2/4_C-subdom1.
DR InterPro; IPR039863; DKK1-4.
DR PANTHER; PTHR12113:SF31; DICKKOPF-RELATED PROTEIN 3-LIKE; 1.
DR PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
DR Pfam; PF21481; DIKK1-2-4_C-subdom1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 32..78
FT /note="Dickkopf N-terminal cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF04706"
FT DOMAIN 87..116
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 1"
FT /evidence="ECO:0000259|Pfam:PF21481"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 173 AA; 19109 MW; BF090DFFBFC192BC CRC64;
MLNMPHSLPK EVPMAPRDSS LPANTKGSPG VCDHDRACGR SYSCDRHFGL CVPLRGEGQY
CRRDTQCVRG LSCMFGKCHR RIPEGQQGAR CKVDRDCGES MCCARHHGEQ VCKRRLLVGE
SCFVPDGGLA FSINQICPCD EGLLCRGATK PHKREREFIH PGTTSWTCQA PSS
//
