ID A0A3P8XKZ2_ESOLU Unreviewed; 791 AA.
AC A0A3P8XKZ2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Leucine rich repeat and fibronectin type III domain containing 5 {ECO:0000313|Ensembl:ENSELUP00000003843.1};
GN Name=LRFN5 {ECO:0000313|Ensembl:ENSELUP00000003843.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000003843.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000003843.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000003843.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010876991.1; XM_010878689.2.
DR AlphaFoldDB; A0A3P8XKZ2; -.
DR STRING; 8010.ENSELUP00000003843; -.
DR Ensembl; ENSELUT00000013345.2; ENSELUP00000003843.1; ENSELUG00000005030.2.
DR GeneID; 105015492; -.
DR KEGG; els:105015492; -.
DR GeneTree; ENSGT00940000158296; -.
DR InParanoid; A0A3P8XKZ2; -.
DR OMA; NGQHKAT; -.
DR OrthoDB; 2942402at2759; -.
DR Proteomes; UP000265140; LG15.
DR Bgee; ENSELUG00000005030; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05764; IgI_SALM5_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF10; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..791
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017968186"
FT TRANSMEM 525..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 287..373
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 381..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 791 AA; 87172 MW; E935155C5B22233D CRC64;
MEKLLVCLLV FGMAVKAQIC PKRCVCQILS PNLATLCAKK GLLFVPPNID RHTVELRLAD
NFVTSIKRKD FANMTRLQDL TLSRNTISFI TPHAFADLEN LRALHVNSNR LTRIANETFS
GMSKLHHLIL NNNQLTLIHL GAFNDLLALE ELDLSYNNLE SIPWEAIQRM TSLHTLSLDH
NMIEYIPEGT FSLLQKLNRL DVTSNKLQKL PPDPLFQRAQ VLATSGIMNP SSFALSFGGN
PLHCNCELLW LRRLSREDDL ETCASPQHLS GRYFWSIPEE EFLCEPPLIT RYSHEMRVLE
GQRISLRCKA RGDPEPAIHW ISPEGKLVSN SSRTLVYANG TLDILITTVK DTGSFTCISS
NPAGEAHQTM ELQIIKLPHV PNSTNNIQEP DPGSSDISTS TRAGANGSNH TGDTKTSPDK
RVVIAEATSS TALIKFNFQR NIPGIRMFQI QYNGSYDDSL VYRMIPPTSK NFLVNNLAAG
TSYDLCVLAI YDDGITSLTA TRVVGCVQFT TESEYLRCHF MQSQFLGGTM IIIIGGIIVA
SVLVFIIILM IRYKVCNTSD SGKGTLVTNV HSQTNGAQSQ GCTVTPSVSK HAMGGQDGAG
GECLKAAGHL PDTLTHSSET SLPDCSTATS LDSQSRNTPG SSGTLKPKRK PAPKPSAAAA
VPEPKIEALP NAETQNTNLN NSTTLQQPPA PVYRTHLTSS HVKDTPILRR VHRRSSSKYL
TLPVEGMRSK RRYSLNEDSS KHHYCYIGAT KLGNMWSKRS VSMNGMLLQQ EDMDSGKATF
SSSEWILEST V
//
