ID A0A3P8XLM3_ESOLU Unreviewed; 418 AA.
AC A0A3P8XLM3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=SH3 and cysteine-rich domain-containing protein 2 {ECO:0000313|Ensembl:ENSELUP00000005452.1};
GN Name=STAC2 {ECO:0000313|Ensembl:ENSELUP00000005452.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000005452.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000005452.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000005452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}.
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DR RefSeq; XP_010862556.1; XM_010864254.2.
DR AlphaFoldDB; A0A3P8XLM3; -.
DR STRING; 8010.ENSELUP00000005452; -.
DR Ensembl; ENSELUT00000010643.2; ENSELUP00000005452.1; ENSELUG00000006477.2.
DR GeneID; 105005969; -.
DR KEGG; els:105005969; -.
DR GeneTree; ENSGT00950000183092; -.
DR InParanoid; A0A3P8XLM3; -.
DR OMA; QQACNGK; -.
DR OrthoDB; 3716527at2759; -.
DR Proteomes; UP000265140; LG05.
DR Bgee; ENSELUG00000006477; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR039688; STAC1/2/3.
DR PANTHER; PTHR15135:SF5; SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15135; STAC; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF16664; STAC2_u1; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 130..181
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 301..360
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 46490 MW; D45EAD076C1EAADC CRC64;
MTENSEKENE PQHRDLHRCP STVPILPESK LQRLKRSLSL KSVMRSKSVD NFFQRGSNGE
LPPLSGIIHE SPPPPPSPPP FGETLPTCER SPSLSPSISP NPSLASHSPS LSPSLSMTSK
TQLQARPVKT HCFQEHVFRR PTCCQQCKHV IQGNSKQGLR CKSCKLGAHL WCSSELSQQP
CTGKTGAFKR NFSSPLLTND MLGVVKEVLP SQESSKGRVD PVYEALRYGT SLAQMGRSSC
GGINTDSPSH EVERVEEGLE TQPIAEEEFV PETETPTPPE GEKADSEDRV SLKTPKCIDV
HSVHTYVALY KFLPQEKNDL ELQPGDRVQV TDDSNEDWWK GKSKDKLGYF PANFVQRVRP
GERVWKVTGA FQGDRNRGQM TVKDFQICVG KNEEIDGFLK LSSGKKRGLV PSKYLLEI
//
