ID A0A3P8XNP2_ESOLU Unreviewed; 451 AA.
AC A0A3P8XNP2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Insulin-like growth factor 2 mRNA binding protein 3 {ECO:0000313|Ensembl:ENSELUP00000004813.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004813.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000004813.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000004813.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC {ECO:0000256|ARBA:ARBA00009094}.
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DR AlphaFoldDB; A0A3P8XNP2; -.
DR Ensembl; ENSELUT00000011711.2; ENSELUP00000004813.2; ENSELUG00000005947.2.
DR GeneTree; ENSGT00940000154957; -.
DR OrthoDB; 3035007at2759; -.
DR Proteomes; UP000265140; LG10.
DR Bgee; ENSELUG00000005947; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.310.210; -; 2.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR10288:SF158; INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 3.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00322; KH; 3.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 3.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..75
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 451 AA; 49552 MW; 86948776883006E6 CRC64;
MNKLYIGNVS EEASAEDLET IFEQWKIPHS GPFLVKTGYA FVDCPDEKVA MKAIDILSGK
VELHGKLLEV EHSVPKRQRS CKLQIRNIPP HMQWEVISLM GRVTSRYRAC TPAVKREKKT
LPSSLLPPSR IDIHRKENAG AAEKPITVHS TPEGCSSACR TIMEIMQKEA LDTKFTEEIP
LKILAHNNFV GRLIGKEGRN LKKIEVDTET KITISPLQDL TLYNPERTIT VKGSIEACSR
AEEEVMKKIR ESYENDVAAM NLQSNLIPGL NLNALGLFPG GAPGMGPSMA NAPPPGAQPE
SETVHLFIPA LAVGAIIGKQ GQHIKQLSRF AGASIKIAPP DSIDTKQRMV IIAGPPEAQF
KAQGRIFGKL KEENFFGPKE EVKLEAHIKV PSFAAGRVIG KGGKTVNELQ NLTSAEVVVP
RDQTPDENDQ VIVKITGHFY ASQVCYSTTM Q
//
