ID   A0A3P8XPR2_ESOLU        Unreviewed;       920 AA.
AC   A0A3P8XPR2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=MutL homolog 3 {ECO:0000313|Ensembl:ENSELUP00000006541.2};
GN   Name=MLH3 {ECO:0000313|Ensembl:ENSELUP00000006541.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000006541.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000006541.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000006541.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8XPR2; -.
DR   STRING; 8010.ENSELUP00000006541; -.
DR   Ensembl; ENSELUT00000008764.2; ENSELUP00000006541.2; ENSELUG00000007401.2.
DR   GeneTree; ENSGT00800000124176; -.
DR   Proteomes; UP000265140; LG15.
DR   Bgee; ENSELUG00000007401; Expressed in ovary and 14 other cell types or tissues.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          681..859
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          128..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   920 AA;  102104 MW;  4A465788CA1544BD CRC64;
     MYVINIKCHY SEYDICFEPA KTLIEFKAWE TLIVCIEEAV KAFLKRENLV CELSPEDILD
     DVSQNVFSGQ MTSADGGKDS IGKDVQPQME GVALECNIGR TLASEAVHRR PTEGSCKKEC
     VCQSYDGVKS EGDKKDEQGD GEVPEGCEQE QVHYPTNRQS EPSSSDTLRE ALQFDSKMYS
     SVINCSGYES YKDITKENKS DAYISEGFCA ESSQHGLIYT KSEHQKISLK GGTEINNARM
     QVSPSKCVVR APDSVSDSNH SETVSIKHSP PQIQNKEHNL GEQKNIFISD PYIHSSSISP
     KYTHHKSRKG LALESSEIPA TKRKLTVVEG PGLIKIGEKK SKDLPNAIPA KISKLMSYQK
     LALHKEPGSL DRFRRTYGKP ANSKPLSNNV SNNLAMDASI SQTEFAAINA KTVLPLHETN
     QENDIKKSRL DQMKDHKSSL TLSMSMKVNP LTTQSRSNMS SLAAKLSHLK HLRTGVTSSA
     FEHPPKATSS EDLGFPETVT NGTLLDINAE EKYNDRSLNL NFNTKLPLDE KEENKVTASS
     DWLHHYDDAV GKLVYVNKVT GLSKYEAPPA EETQARCTSD VSNMAISVTS KNGVEYRCYP
     FQMNLVLPFL PKSKPGRVLN DILNPNSLSS LYSSWANPVF ARPPMIGVDI SSGKAEGLAV
     KIHNILFPYR FSKDMIHSMK VIHQVDKKFL ACLINTQDHE PAACGNLLVL VDQHAAHERV
     RLEKLVADSY EDDSEAVGGR LLCSSTVTPP LEVSVTEDEL RLLRSCQTFW RALGLEMQFS
     QTEPLVLVRK VPMCFTEKES NELRRGRQSV IKGIVGEYLQ EQIESLRSTG RVKGTLPLTV
     LKVLASIACH GAVKFNDRLS KEECCSLVGC LSLCQLPFQC AHGRPSIAPL VDILHLNDQE
     VPQLANTKSA MMWSLQTHFA
//