ID A0A3P8XPX8_ESOLU Unreviewed; 657 AA.
AC A0A3P8XPX8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Fermitin family member 3b {ECO:0000313|Ensembl:ENSELUP00000006560.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000006560.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000006560.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000006560.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR AlphaFoldDB; A0A3P8XPX8; -.
DR STRING; 8010.ENSELUP00000006560; -.
DR Ensembl; ENSELUT00000008731.2; ENSELUP00000006560.2; ENSELUG00000007439.2.
DR GeneTree; ENSGT00390000013444; -.
DR InParanoid; A0A3P8XPX8; -.
DR OMA; PNRRMIR; -.
DR OrthoDB; 5399911at2759; -.
DR Proteomes; UP000265140; LG04.
DR Bgee; ENSELUG00000007439; Expressed in head kidney and 14 other cell types or tissues.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17185; FERM_F1_KIND3; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF1; FERMITIN FAMILY HOMOLOG 3; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 342..453
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 657 AA; 74999 MW; B0B8D6E0B70BBBF5 CRC64;
MAVWDLSVTL EDLGAEAPPI TVSVTSDLHI GGVILKLVEK SQVRRDWSDH ALWWEQKQQW
LLRPSWTLEK CGIHADARLI FMPQHKALKL GLPNGLTIRV RACFSGSVFR TVLGICKMLN
IRRPEELSLL RPVEEKKKKK DKDLSEEVYD LTDAIKVAVN TVHSLCDPVL TDLPSCLVSR
PCLYNGMPAH FADSPKTEKV YKMLSVPQPA PAPEAIAKLY RPASIVDKAH IHSRWLDSSR
SLMQQGVQEN DRLWLRFKYY CFHDMEPKYD AVRLTQLYEQ ARWAILLEDI DCTEEEMMLF
GGLQYHINKL SLSEPQAMTS TPAMDDLDSA LQCLEVKLDV GGSSPQDLLV RYDDSKFHIT
PKRLTLKGYK QYWFKFKDDS ISYYKSKEES LGEPIQQINL KGCEVAPDVN VAGQKFCIRL
LIPAPEGMNE VYLRCENEEQ YSRWMAACRL ASKGKSLADT SFQSEIQSIR SFLAMQQTNP
STNSSQTDDN INTHSLVSPR YSKKYKTKQL APKILDAYQN VAQLSLTDAL LRFLQIWQAL
PDFGLSFVVV RFKGSRKDEV LGIAPNRLIR IDLGVGDVVK TWRYNNMRQW NVNWDIRQVA
IEFDGNVNIA FCCVTADCKI VHEFIGGYIF MSTRSREQSD TLNEELFHKL TGGHEAL
//
