ID A0A3P8XQU4_ESOLU Unreviewed; 1022 AA.
AC A0A3P8XQU4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Solute carrier family 12 member 10, tandem duplicate 1 {ECO:0000313|Ensembl:ENSELUP00000005633.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000005633.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000005633.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000005633.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3P8XQU4; -.
DR Ensembl; ENSELUT00000010331.2; ENSELUP00000005633.2; ENSELUG00000007246.2.
DR GeneTree; ENSGT00940000155044; -.
DR Proteomes; UP000265140; LG24.
DR Bgee; ENSELUG00000007246; Expressed in liver.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF97; SLC12A10.3 SOLUTE CARRIER FAMILY 12 (SODIUM_POTASSIUM_CHLORIDE TRANSPORTERS), MEMBER 10, TANDEM DUPLICATE 3 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 142..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..99
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 147..652
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 661..795
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 822..1021
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 30..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1022 AA; 113736 MW; 47C0E08BC69410F9 CRC64;
MADPEVLPNG RFSLSEDVLP RYAFERRPRG TVTFDSHMPA SSGTTDTELP DTERRDSRID
GRRSSIYSTM DPVPQLDFYA HSSMTGRQQR SRPSLDILRK SFDVCIWSCS PAEMSTQKDE
SGIVQQDTSF SEGEKPFVPV RFGWVTGVMV RCMLNIWGVI LFLRLSWITS QAGIILTWLI
ILMSVIVTSV TALSVSAIST NGRVVSGGAY FMISRTLGPE MGGPIGVVFS FANALACALN
TVGFAEVVRD MLVEYDALMI DEVNDVRIIG VVTICLLLLI SMAGMEWEAK TQWLFFIVLM
VSFANYFVGT VIPVPEKEAM GFFSYHSEIF MSNLLPDWRG PDGSFFQMFA IFFPSAIGIL
SGVNICGDLK DPSSAIPKGT LAAIFGTTIS YLAISATAAS CVVRDASGNP NDSLSANFSE
PCNGLGCKLG WNFTECEETK SCAFGLANSF KILSLASGFG GLITAGVFAA SLSSALAFLV
SAPKVFQCLC RDNIYPYIGF FAKGYGKNDE PLRAYLLTFF IAVAFILIAE LNIIAALISN
FFLCSYALIN FSCFHASITN SPGWRPSFRY YSKWASLFGA VVSVVLMFLL TWWAALITFC
VIMFLLGYVT YNKPKINWGS SVQAGTYNMA LSYSVSLAGV EDHVKNFRPQ CLVLTGPPNV
RPALVDFVGS FTKNISLMIC GDILMVSGGT IYGQIMFESH ILVKWLNRRK VRSFYTPFTG
DCLREGAKHL LQASGLGKLK PNTLIMGFKN NWKECTPHSM EDYVNTIYDT FDSNYGVCLL
RMMDGLDLSE GIQYSNLSPL LFSCGFAVDL PSGAVLNDQI KTVFQSKQGK KTIDVYWISD
DGGLTLLVPY LLSRRKRWRQ SKVRVFIVGE EHTIEEDRKE MILLLQKFRL DIHDVIIMTD
SEKPPQAKNL KRFEDTVALF RLRDEQQAES VVQQLRKDYP WKISDKELEA LRQKSERKVR
LNEIIRRNSQ QAALVLVSLP VPQLDCPSAL YMAWLDTLTC GLPCPTALIR GNQQNVLTFY
CQ
//
