ID A0A3P8XQX6_ESOLU Unreviewed; 647 AA.
AC A0A3P8XQX6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Histidine ammonia-lyase {ECO:0000256|ARBA:ARBA00017271, ECO:0000256|RuleBase:RU004479};
DE EC=4.3.1.3 {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|RuleBase:RU004479};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000006966.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000006966.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000006966.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000171,
CC ECO:0000256|RuleBase:RU004479};
CC -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00005113, ECO:0000256|RuleBase:RU004479}.
CC -!- SIMILARITY: Belongs to the PAL/histidase family.
CC {ECO:0000256|ARBA:ARBA00007238, ECO:0000256|RuleBase:RU003954}.
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DR AlphaFoldDB; A0A3P8XQX6; -.
DR STRING; 8010.ENSELUP00000006966; -.
DR Ensembl; ENSELUT00000008044.2; ENSELUP00000006966.2; ENSELUG00000007804.2.
DR GeneTree; ENSGT00390000009047; -.
DR UniPathway; UPA00379; UER00549.
DR Proteomes; UP000265140; LG19.
DR Bgee; ENSELUG00000007804; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR005921; HutH.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR NCBIfam; TIGR01225; hutH; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 3: Inferred from homology;
KW Histidine metabolism {ECO:0000256|ARBA:ARBA00022808,
KW ECO:0000256|RuleBase:RU004479};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU003954};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 12..81
FT /note="Par3/HAL N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12053"
SQ SEQUENCE 647 AA; 71292 MW; 3E4706B7A6CC0C3E CRC64;
MPRYTIHIRD EWLTVPCRDS TYTIQWLGHE ALKRYTKNKP DNGGIKKAVT DIKFFARRCQ
GQGLLDEDDT IEDVLEDNDF VEIAIEGDAM SSDFIPYQPG VSQLYPSIYL FLDGNSLTST
DLVNLGKGLY KIKLSPEAEN GVVKSRELLD TIVKENKVVY GITTGFGKFA RTVIPVHKLK
ELQENLVRSH SAGVGSPLTP ERTRMLLALR INVLAKGYSG ISLETLHRMI EAFNASCLSF
VPEKGTVGAS GDLAPLSHLA LGLMGEGKMW SPKSGWADAK YVLEAHGLKP ISLKPKEGLA
LINGTQMITS LGAEAVERAL AIARQADIIA AITLEVLKGT SKAFDSEIHA LRPHSGQIEV
ARRFRSLLHS DHHPSEIAES HRFCDRVQDA YTMRCCPQVH GIVNDTIDFA KKIINTEINS
ATDNPISFTG SEGETISGGN FHGEYPAKAL DFLAIGVHEL AAISERRIER LCNPSLSELP
AFLVNEGGLN SGFMIAHCTA ASLVSENKVL CHPSSVDSLS TSAATEDHVS MGGWAARKAL
RVVEHVEQVL AIELIAACQG IEFLRPLRTT TPLEKVYDLV RSVVKPWIKD RFMSPDIEAV
HRLLLDQKVW HVAQPYIERY NMEFLPESRP SSPTAFSLDP PASPRKL
//
