ID A0A3P8XR71_ESOLU Unreviewed; 583 AA.
AC A0A3P8XR71;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=MARVEL domain containing 2 {ECO:0000313|Ensembl:ENSELUP00000006239.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000006239.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000006239.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000006239.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family.
CC {ECO:0000256|ARBA:ARBA00009171, ECO:0000256|PROSITE-ProRule:PRU01324}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010894338.1; XM_010896036.3.
DR RefSeq; XP_010894339.1; XM_010896037.3.
DR AlphaFoldDB; A0A3P8XR71; -.
DR STRING; 8010.ENSELUP00000006239; -.
DR Ensembl; ENSELUT00000009285.2; ENSELUP00000006239.1; ENSELUG00000007149.2.
DR GeneID; 105025395; -.
DR KEGG; els:105025395; -.
DR GeneTree; ENSGT00940000155771; -.
DR InParanoid; A0A3P8XR71; -.
DR OMA; TECSINF; -.
DR OrthoDB; 2910197at2759; -.
DR Proteomes; UP000265140; LG13.
DR Bgee; ENSELUG00000007149; Expressed in pharyngeal gill and 10 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 6.10.140.340; -; 1.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR010844; Occludin_ELL.
DR PANTHER; PTHR23288:SF41; MARVEL DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR Pfam; PF01284; MARVEL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR SUPFAM; SSF144292; occludin/ELL-like; 1.
DR PROSITE; PS51225; MARVEL; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 217..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 213..385
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT DOMAIN 466..577
FT /note="OCEL"
FT /evidence="ECO:0000259|PROSITE:PS51980"
FT REGION 28..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..153
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 64691 MW; 7BDD5B768D55DE24 CRC64;
MSAGGGFTGR FDRVRDPEPY YDQVPVASLW RAPPPPPPGA LGANLAVSMD PLPPPPLPEQ
PPVGSDFFPT SNGTSERLDD DSAAMDIKPV RRFIPDSVKN FFRGSSILGS KKPLTLPAPP
SPPLTEKDDL KPGSTGGVPC SPPHSPHPSP SLPRSYLDPY GGSGGSYNSR KEHDALLLGA
EAGESVSGRT FRSAMTYSEK VEDYNQRYAY MKSWAGLLRI LGCVELLLGA VVFACVCASI
HKDSEWFNLF GYSQPQMFGG GGYNSYNGPM TPFVLVVVGL AWIVTIIILV MGMTMYYRTI
LLDSSWWPLT EGAINLAMVF LYLAGGVVYV RDTTRGGMCY YPMFNNGVNG KFCRTEASQN
AALIFLFVNM VVYFVGAGVC MKLWRHEAAR LRREALAQEM KTIGSSLPIP VLAGSRTSEQ
TPLPTLHMIP EVDGNNFSAA APLMMEPEIL RGHIPSGHIP KPVVIADYVA KYPTIRTEEA
RDQYKAVFKD QYAEYKELHA EVQAMSLKFE EMDEIMRSLP SRPSSQMEKE RIDNLMLEYQ
KKKADPTFLE KRERCEYLKN KLSHIKLKIN EYNKVMDWND GFG
//
