ID A0A3P8XUC5_ESOLU Unreviewed; 662 AA.
AC A0A3P8XUC5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Nuclear receptor subfamily 4 group A member 2 {ECO:0000256|ARBA:ARBA00019630};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000008107.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000008107.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000008107.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR RefSeq; XP_019896640.1; XM_020041081.1.
DR AlphaFoldDB; A0A3P8XUC5; -.
DR STRING; 8010.ENSELUP00000008107; -.
DR Ensembl; ENSELUT00000006125.2; ENSELUP00000008107.1; ENSELUG00000008799.2.
DR GeneID; 105018906; -.
DR GeneTree; ENSGT00950000183038; -.
DR InParanoid; A0A3P8XUC5; -.
DR OMA; DFIPYTH; -.
DR OrthoDB; 5395768at2759; -.
DR Proteomes; UP000265140; LG20.
DR Bgee; ENSELUG00000008799; Expressed in muscle tissue and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0001780; P:neutrophil homeostasis; IEA:Ensembl.
DR CDD; cd06969; NR_DBD_NGFI-B; 1.
DR CDD; cd06945; NR_LBD_Nurr1_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; NR4A1-3.
DR InterPro; IPR003073; NR4A2.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24085:SF2; NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR01287; NURRNUCRCPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 324..399
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 426..660
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 171..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 72380 MW; 8BE02C3BCCE1C4A4 CRC64;
MCGVITPVRK SAPSRAQIPG YRTVLRSPPR TGALTIAAPA PSPPHRAPFS ARLSHQIYGI
LTMNKRAQLL EQMHCVQLKC TPRDMPCVQA QYGPTPPGSS YSAQSFGYQG DSYSSDLMAP
DYSKLDLGGG EISAAATTSL PSFNVFVEGS YEPKSSCLYQ LPSHRPLIKK EEESYPQSAP
PPLDTLPSSS MYFKQSPPST PTTPSLPPQP GSSFLWDESP HHSLQPPSHG PIKSPRFSHF
YQHSPPHSGG YEGLGGGLPR SSPSSVPSRP HGPPLEQHLY QLHRGVGGPG GPGGLAFRSL
ALGSCNPLLG DGLPSPPPRG PPGEGTCAVC GDNAACQHYG VRTCEGCKGF FKRTVQKNAK
YVCLASKNCP VDKRRRNRCQ YCRFQKCLSV GMVKEVVRTD NLKGRRGRLP SKPKSPLQTE
SSPPSPPLSL LSALLRAYSH CTPRELDYSQ FSAAEATSSS SDAQNIELFY RLLTVSMETT
RCWADRLPGF NELHRDDQNL LIDSAFLELF VLRLAHRSLL SEDKLVFCNG LVLSRFQCLR
GFGEWLDSIR DFSSHLQSLN LDTSAFSCLA ALVLLTEQVP GLKDSKRVEE LQNKVVCCLK
DHLGFGPSSS SKATPALSRV LGVRAELRSQ RTQGLQRIFY LKLEDLVPPP PLIDRFLDTL
PY
//
