ID   A0A3P8XVC3_ESOLU        Unreviewed;       887 AA.
AC   A0A3P8XVC3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Whirlin a {ECO:0000313|Ensembl:ENSELUP00000008428.2};
GN   Name=WHRN {ECO:0000313|Ensembl:ENSELUP00000008428.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000008428.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000008428.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000008428.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8XVC3; -.
DR   STRING; 8010.ENSELUP00000008428; -.
DR   Ensembl; ENSELUT00000005578.2; ENSELUP00000008428.2; ENSELUG00000009088.2.
DR   GeneTree; ENSGT00950000183002; -.
DR   InParanoid; A0A3P8XVC3; -.
DR   OMA; TMVNQTR; -.
DR   Proteomes; UP000265140; LG14.
DR   Bgee; ENSELUG00000009088; Expressed in camera-type eye and 4 other cell types or tissues.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   CDD; cd07357; HN_L-whirlin_R2_like; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   Gene3D; 1.20.1160.20; -; 2.
DR   Gene3D; 2.30.42.10; -; 3.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR033028; Whirlin_HN-like_dom2.
DR   PANTHER; PTHR23116; PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED; 1.
DR   PANTHER; PTHR23116:SF37; WHIRLIN; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   PROSITE; PS50106; PDZ; 3.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          136..207
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          275..345
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          796..867
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          236..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          536..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..555
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        674..699
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        734..752
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   887 AA;  96218 MW;  F81E1D6DBDC9C753 CRC64;
     MTNVSPTDLE RMSLNSSANS VASSARTLSA NVKKLHNALN LLLNDFEREQ FIHCLNVYHS
     KRNVYDLVQT LKVILNAPSK RQLLPMLRLV IPRSDQLLFD QYTSEGHFSP TPPGSQVALR
     GSPDRFLHEP PGEVRQVTLK RHKSNEGLGF SIRGGSEHGV GIYVSLVEPG SLAEKEGLRI
     GDQIMKVNNT MFDKVTHAEA VKVLKGSKKL SLSVRSVGRI PGGYVTNHVY TWVDPQGHSV
     SPPPDLPEHH SASLRRADSQ RRSNMQLLQE GDEKKVNLVL DDGRSLGLMI RGGAEYALGI
     YITGVDRGSA AECGGLKVGD QILEVNGCSF LGVPHDEAVR VLKSSRHLMM TVKDVGRLPH
     ARTVVGETKW ITSSQIAESS AVLFFIVITA KGLNGLMMFY KGMAGSQVTL SSLVNQSRAM
     LEEQARHLLT ETERQTMGYY VEEYREGHIG VEPLVMALFE LLNTHAKFSL LSEVRGLVTP
     QDLERFDGMV LRREIQALKA RQGGAGAAAL HPDSLSVVSY PDTMASSSAS YMTSTTLSSA
     RNDGTVESNG EESQGSLDAL PDVSLDEVHS TSESPPTFKP PPPPGVQRSP SRRDQVKKRT
     SSESSNSGLY FTAPSRNPPI EPSSPKVIPK KDPSAPLKRD PSALRKEMAT TQLSKVSQHP
     IGPFPRVQSP TRTKPVAPSP PPPPPLPAPS APPPQRPDKA SPGSNKQRFV MVEVHRPNGE
     SDVNEVRSLP RTRGATLSRL SDGGQTLSED SGVDIGESGR LGKESSPRPT HTRPQRGTVG
     DAPTKPPGLL EPTSILVRVA KSASTLGIAI EGGANTRQPL PRIVTIQRGG SAHNCGQLRV
     GQVILEVNGV SLRGREHREA ARLIAEAFKN KDKDHVDFLV TDFNVAL
//