ID   A0A3P8XVS0_ESOLU        Unreviewed;       859 AA.
AC   A0A3P8XVS0;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000008582.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000008582.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000008582.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_010869593.1; XM_010871291.3.
DR   AlphaFoldDB; A0A3P8XVS0; -.
DR   STRING; 8010.ENSELUP00000008582; -.
DR   Ensembl; ENSELUT00000005324.2; ENSELUP00000008582.1; ENSELUG00000009232.2.
DR   GeneID; 105011338; -.
DR   KEGG; els:105011338; -.
DR   GeneTree; ENSGT00940000155050; -.
DR   OrthoDB; 5471864at2759; -.
DR   Proteomes; UP000265140; LG08.
DR   Bgee; ENSELUG00000009232; Expressed in bone element and 15 other cell types or tissues.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR   InterPro; IPR032353; AZUL.
DR   InterPro; IPR042556; AZUL_sf.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF16558; AZUL; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          531..859
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          153..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..191
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        827
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   859 AA;  98456 MW;  1BEAEC6CEED971FD CRC64;
     MKRAAAKHLI ERYFRQLTEG CGNGACTNEF CASCLGFQPM DNNAAAVRAL ELYKINAKLC
     DPHPSKKGIS AAFPDNHSAK DTHAALMGDH ERKMTDKDDL LPPREDFREV HYLTEDKVYE
     ILSICEGKRD YSPLIRVIGR IFSSADGLVQ SFRKDQGQHK PHTKEQRKAH QGKDEDKDED
     EKERSTAMDQ ESEESEASAS SRGAAAAESR LGPVEVSVDV EAVRRVYARL LSNETIEAAF
     LNALVYLTPH VELDLTYLDV YDTNPDYLNI FVIVMENSNL HSPEYLEMAM PLFCKCMSKL
     PLPALAKLTR LWSQYSIEQI RRMMETFQQL ITFTVISNEY DSEHLVNDDD CVVAAAKCLK
     LVFYANVLGG DLDTDHNEDE EEEPASESSE LTLQELLGEE RRNKKGPRID PLEKELGIRT
     LDCRQPLIPF EEFVNEPLND VLEMDKDFTF FKVDSESKFS FQTCPFILNA CTKSLGLYYD
     NRISMYSERR ITALYSLVQG QQLNPYLRLK VRRDHIIDDA LVRLEMIAME NPADLRKQLF
     VEFEGEQGVD EGGVSKEFFQ LVLEEMFNPD IGMFTYDEST KLFWFNPSSL ENEAQFTLIG
     IVLGLAIYNN CILDVHFPMV VYRKLMGKKG TYLDLADSHP VLYQSLKELL EYEGNVEEDM
     MITFQISQTD LFGDPITYDL KEHGDKIPVT MENRKEFVSL YAEYILNKSV ERQFKAFRRG
     FQMVTNESPL KCLFRPEEVE LLICGSRNLD FYALEETTEY DGGYHKDCRI IKDFWETVHS
     FSDEDKRLFL QFTTGTDRAP VGGLGKLKMI IAKNGPDTDR LPTSHTCFNA LLLPEYDTKE
     KLKERLLKAI TYAKGFGML
//