GenomeNet

Database: UniProt
Entry: A0A3P8XYY7_ESOLU
LinkDB: A0A3P8XYY7_ESOLU
Original site: A0A3P8XYY7_ESOLU 
ID   A0A3P8XYY7_ESOLU        Unreviewed;      1912 AA.
AC   A0A3P8XYY7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000009656.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000009656.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000009656.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001490};
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Ensembl; ENSELUT00000003487.2; ENSELUP00000009656.2; ENSELUG00000001468.2.
DR   GeneTree; ENSGT00940000153617; -.
DR   Proteomes; UP000265140; LG25.
DR   Bgee; ENSELUG00000001468; Expressed in brain and 8 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd00063; FN3; 8.
DR   CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR   CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR46957:SF1; PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ; 1.
DR   Pfam; PF00041; fn3; 7.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13927; Ig_3; 2.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00014; FNTYPEIII.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 8.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 5.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   PROSITE; PS50853; FN3; 8.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1263..1286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          26..110
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          128..223
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          231..313
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          320..410
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          415..511
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          513..606
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          611..708
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          713..812
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          813..907
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          911..1005
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1010..1094
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1357..1612
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1532..1603
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   DOMAIN          1644..1903
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1821..1894
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          399..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1912 AA;  212804 MW;  3706B27050538253 CRC64;
     LFHVSRSCFL SPSFLSLSLS SSFSPPKFTR TPEDQTGVQG GVASFVCQAT GDPPPKIVWN
     KKGKKVQNQR FEVIDYEDGS GSVLRVQPLR TPRDEAVYEC HASNPAGEIT ALCRLNVLRE
     DQLPPGFPTI DMGPQLKVVE RSRTATMLCA ASGNPDPEIT WFKDFLPVNT TNNNGRIKQL
     RSGGTPIRGA LQIELSEEQD QGKYECVATN SDGTRYSTPA NLYVRVRRVP PRFSIPPADS
     EIMPGGNINI TCVAVGSPMP YVKWMLGAED LTPEDDMPIG RNVLELGDVR QSNNYTCVAM
     STLGVIEAVA QITVKALPKA PGSPVVTERT ATSITLTWDS GNPEPVSYYI IQHRPKGSED
     AYKEIDGIAT TRYSVGGLSP FSHYDFRVAA VNTIGRGPAS DPVEARTAEQ APSSPPRQVR
     GRMLSTTTAI IHWDEPEEAN GQVVGYRVYY TDDPALQVNQ WEKQMVRAAN FITVHSLVPN
     KTYYIRVLAF TSVGDGPLSQ DLQIIAKTGV PSQPSDFKGE AKSETSILLS WVAPPQSGPD
     NQITGYELVW RRADDTEEKK LSFDPTTSYL MKNLKPFSSY TFQLAARSKH GIGAFTNEVT
     ADTPQTLPSA PPQDVTCSSP SSTSILVSWA PPPPEYQNGI ITGYSIQYSV TEGQNRTSKK
     ISAIPPNSSP YLLENLEKWT EYGITVRALT ETGEGPESLQ RLVRTEEDVP SGPPRGVETE
     AVNSSAIRVA WRAPAAERQH GQVRGYQVHY VKMSYGEPTG PNLIKDILID DSQEVVLGDL
     QANTGYSVSV GAYTAKGDGA RSKPQTVCTT LAFPERPRLS VSSSVAGTAQ LQWLPPPDPP
     TPLLGYRLTF GRLDVLPLTV VEFPAKETSF RAQDIHKGTT YIFKLSARNK IGYGEEAAIK
     LTTPEDAPKG YPENIISEGA SSSSLQLAWK SVPLIEQNGK IVKYSVQYRD VNARGNTTRE
     VAVPEAGVTL EGLSADTVFD VRVRAFTAVG PGPYSPSVQF RTQPQEVEVF ATNFRVKAAM
     KTSVLLTWEI PEKNPSQPFT ILYGKGQSVE VDGKLAQKLI TGLQPETQYS FLLTNRGNSA
     GGLQHRVTVT TAPDMLRSKP TLVGKTNADG MVTVQLPPVQ APVPVRGYYV VVVPLKKQRA
     GKFLKPWENP DQMNLDELLK EINRTSVSRA LRVRRQIPAS QSDPKAYISA HFTTLPLEFT
     LGDGQSYGEF RNRPLQNGQE YVFFVLALLD QADHTMYSTS PYSDPVTSND VDPQPIIDEE
     EGLLWVVGPV LAVIFIVCIV IAILLFKSKP DRKRAEAEGR KASFPCSKAM SSQHPTDPVE
     LRRINFQTPG MVSHPPIPIS ELADHIERLK ANDNLKFSQE YESIDPGQQF TWEHSNLEVN
     KPKNRYANVI AYDHSRVLLS SIEGIPGSDY INANYIDGYR RQNAYIATQG SLPETFCDFW
     RLIWEQHTAN IVMMTKLEEK SRVKCDQYWP TRGTETYGLI QVTLLDTVEL ATYSVRTFAL
     YKSGSSEKRE VRHFQFTAWP DHGVPEHPTP FLAFLRRVKA CNPPEAGPMV VHCSAGVGRT
     GCFIVIDAMV ERIKHEKTVD IYGHVTLMRS QRNYMVQTED QYAFIHDALL EAVACGNTEV
     PARKLYAYIQ RLTQIEPAEN VTGMELEFKR LASAKAHTSR FVSANLPCNK FKNRLVNIMP
     YETTRVCLQP IRGVEGSDYI NASFIDGYRQ QRAYIATQGP LAETTEDYWR MLWEHNSTIV
     VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
     RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI TVHCSAGVGR TGVFITLSIV
     LERMRYEGVV DIFQTVKMLR TQRPATVQTE DQYQFCYRAG LEYLGSFDHY AT
//
DBGET integrated database retrieval system