ID A0A3P8XYY7_ESOLU Unreviewed; 1912 AA.
AC A0A3P8XYY7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000009656.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000009656.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000009656.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSELUT00000003487.2; ENSELUP00000009656.2; ENSELUG00000001468.2.
DR GeneTree; ENSGT00940000153617; -.
DR Proteomes; UP000265140; LG25.
DR Bgee; ENSELUG00000001468; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF1; PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1263..1286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 128..223
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..313
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 320..410
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 415..511
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 513..606
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 611..708
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 713..812
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 813..907
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 911..1005
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1010..1094
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1357..1612
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1532..1603
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1644..1903
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1821..1894
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 399..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1912 AA; 212804 MW; 3706B27050538253 CRC64;
LFHVSRSCFL SPSFLSLSLS SSFSPPKFTR TPEDQTGVQG GVASFVCQAT GDPPPKIVWN
KKGKKVQNQR FEVIDYEDGS GSVLRVQPLR TPRDEAVYEC HASNPAGEIT ALCRLNVLRE
DQLPPGFPTI DMGPQLKVVE RSRTATMLCA ASGNPDPEIT WFKDFLPVNT TNNNGRIKQL
RSGGTPIRGA LQIELSEEQD QGKYECVATN SDGTRYSTPA NLYVRVRRVP PRFSIPPADS
EIMPGGNINI TCVAVGSPMP YVKWMLGAED LTPEDDMPIG RNVLELGDVR QSNNYTCVAM
STLGVIEAVA QITVKALPKA PGSPVVTERT ATSITLTWDS GNPEPVSYYI IQHRPKGSED
AYKEIDGIAT TRYSVGGLSP FSHYDFRVAA VNTIGRGPAS DPVEARTAEQ APSSPPRQVR
GRMLSTTTAI IHWDEPEEAN GQVVGYRVYY TDDPALQVNQ WEKQMVRAAN FITVHSLVPN
KTYYIRVLAF TSVGDGPLSQ DLQIIAKTGV PSQPSDFKGE AKSETSILLS WVAPPQSGPD
NQITGYELVW RRADDTEEKK LSFDPTTSYL MKNLKPFSSY TFQLAARSKH GIGAFTNEVT
ADTPQTLPSA PPQDVTCSSP SSTSILVSWA PPPPEYQNGI ITGYSIQYSV TEGQNRTSKK
ISAIPPNSSP YLLENLEKWT EYGITVRALT ETGEGPESLQ RLVRTEEDVP SGPPRGVETE
AVNSSAIRVA WRAPAAERQH GQVRGYQVHY VKMSYGEPTG PNLIKDILID DSQEVVLGDL
QANTGYSVSV GAYTAKGDGA RSKPQTVCTT LAFPERPRLS VSSSVAGTAQ LQWLPPPDPP
TPLLGYRLTF GRLDVLPLTV VEFPAKETSF RAQDIHKGTT YIFKLSARNK IGYGEEAAIK
LTTPEDAPKG YPENIISEGA SSSSLQLAWK SVPLIEQNGK IVKYSVQYRD VNARGNTTRE
VAVPEAGVTL EGLSADTVFD VRVRAFTAVG PGPYSPSVQF RTQPQEVEVF ATNFRVKAAM
KTSVLLTWEI PEKNPSQPFT ILYGKGQSVE VDGKLAQKLI TGLQPETQYS FLLTNRGNSA
GGLQHRVTVT TAPDMLRSKP TLVGKTNADG MVTVQLPPVQ APVPVRGYYV VVVPLKKQRA
GKFLKPWENP DQMNLDELLK EINRTSVSRA LRVRRQIPAS QSDPKAYISA HFTTLPLEFT
LGDGQSYGEF RNRPLQNGQE YVFFVLALLD QADHTMYSTS PYSDPVTSND VDPQPIIDEE
EGLLWVVGPV LAVIFIVCIV IAILLFKSKP DRKRAEAEGR KASFPCSKAM SSQHPTDPVE
LRRINFQTPG MVSHPPIPIS ELADHIERLK ANDNLKFSQE YESIDPGQQF TWEHSNLEVN
KPKNRYANVI AYDHSRVLLS SIEGIPGSDY INANYIDGYR RQNAYIATQG SLPETFCDFW
RLIWEQHTAN IVMMTKLEEK SRVKCDQYWP TRGTETYGLI QVTLLDTVEL ATYSVRTFAL
YKSGSSEKRE VRHFQFTAWP DHGVPEHPTP FLAFLRRVKA CNPPEAGPMV VHCSAGVGRT
GCFIVIDAMV ERIKHEKTVD IYGHVTLMRS QRNYMVQTED QYAFIHDALL EAVACGNTEV
PARKLYAYIQ RLTQIEPAEN VTGMELEFKR LASAKAHTSR FVSANLPCNK FKNRLVNIMP
YETTRVCLQP IRGVEGSDYI NASFIDGYRQ QRAYIATQGP LAETTEDYWR MLWEHNSTIV
VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI TVHCSAGVGR TGVFITLSIV
LERMRYEGVV DIFQTVKMLR TQRPATVQTE DQYQFCYRAG LEYLGSFDHY AT
//