ID   A0A3P8XZ26_ESOLU        Unreviewed;       864 AA.
AC   A0A3P8XZ26;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Calcium-independent phospholipase A2-gamma {ECO:0000313|Ensembl:ENSELUP00000008619.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000008619.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000008619.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000008619.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_012994394.2; XM_013138940.2.
DR   AlphaFoldDB; A0A3P8XZ26; -.
DR   STRING; 8010.ENSELUP00000008619; -.
DR   Ensembl; ENSELUT00000005277.2; ENSELUP00000008619.1; ENSELUG00000009230.2.
DR   GeneID; 105021841; -.
DR   KEGG; els:105021841; -.
DR   GeneTree; ENSGT00940000154738; -.
DR   InParanoid; A0A3P8XZ26; -.
DR   OMA; DMKITIC; -.
DR   OrthoDB; 5477952at2759; -.
DR   Proteomes; UP000265140; LG19.
DR   Bgee; ENSELUG00000009230; Expressed in liver and 15 other cell types or tissues.
DR   GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07211; Pat_PNPLA8; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR045217; PNPLA8-like.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR24185; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   PANTHER; PTHR24185:SF1; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          526..721
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          42..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          387..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..210
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..423
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   864 AA;  93123 MW;  7E9B3A406F2E47A0 CRC64;
     MSLSWAPDRC VLRISRAVKV WQGRHSASFP LRHACQIHVR PSHSRKVGHP GWKSVQSPKS
     RSRGKQWLCR ASQVRHRLGL HTGAGSYASS SRWSAGLSHT MSRFRSTLDS VSKAVSGTHA
     ELLSKIARLR AQPKQKAIEA GRTVDTVPET GLTLPGPGAA GPPAPTSTPA PAPVPAATAS
     TPPPLASPAA PGPPPGTTPG MTPSCPPVAA PTAHPSSSGA AVSEPRLKRV QRAAKAPAVP
     ASGVVNGTAG RGEQSVKPPT AAKTTTTAVS KQTAPLFHPG SLSANLDETY NYLAQHINSY
     FGATQHHGKK AENASNGAIS THRLPVSGKM TAVPAFAATP PSAQSSPKKG FGRYLSYSGD
     TVQAFVGSVG SYIAPLVPRF SRASAATGTP EVESEPLEDE DVGAKQRPRE ATEKMDPKAS
     EERAKRLQLQ REKIIARVSV DNRTRALVKS LQRASEVRVY VNRVEELGYH LLEFPETRGV
     AVKEKVIPCL LRLRQAEDLS LKAAVREALT LVGYSNPVKG WGIRVLSIDG GGTRGLIALQ
     TLQKLEALTG KPIHQLFDYI CGVSTGSILG FMLGLFQIPL NECEVLYRKL GSDVFKQNVI
     VGTVKMGWNH AFYDSETWEN ILKEKMGADL MVETSRNPNC PKVAAVSTIV NRGTPLKAYV
     FRNYNLQPGV RSHYLGGCEH QLWQAVRASS AAPGYFQEFA LGNDLHQDGG LLINNPTALA
     IHECKCLWPD TPVQCVVSLG TGRVETAGKN NTTYTSLKTK LTNVISSATD TEEVHVMLDA
     LLPPDTYFRF NPYMNEDIAL DESRGEKLNL LQAEGLRYLD RNQEKLQKAA RILAQGKSPA
     QRLADWAKLK ADMYDGIPGF SSKL
//