ID A0A3P8Y174_ESOLU Unreviewed; 452 AA.
AC A0A3P8Y174;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Phosphatidylcholine-sterol acyltransferase {ECO:0000256|ARBA:ARBA00040526};
DE EC=2.3.1.43 {ECO:0000256|ARBA:ARBA00039142};
DE AltName: Full=Lecithin-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00042279};
DE AltName: Full=Phospholipid-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00041412};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000010426.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000010426.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000010426.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-
CC acyl-sn-glycero-3-phosphocholine + a sterol ester;
CC Xref=Rhea:RHEA:21204, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=2.3.1.43;
CC Evidence={ECO:0000256|ARBA:ARBA00036617};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
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DR RefSeq; XP_010882327.1; XM_010884025.3.
DR AlphaFoldDB; A0A3P8Y174; -.
DR Ensembl; ENSELUT00000002176.2; ENSELUP00000010426.1; ENSELUG00000010901.2.
DR GeneID; 105018521; -.
DR KEGG; els:105018521; -.
DR GeneTree; ENSGT00940000160052; -.
DR OrthoDB; 239208at2759; -.
DR Proteomes; UP000265140; LG19.
DR Bgee; ENSELUG00000010901; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR11440:SF18; PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE; 1.
DR Pfam; PF02450; LCAT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..452
FT /note="Phosphatidylcholine-sterol acyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018158569"
FT REGION 424..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 51963 MW; B731E4C5D3F34689 CRC64;
MGAYAHCCTL LLIVFLALQQ SAGFWLFDVV FPRSANPQNK VPSNGTPPVL IVPGNLGNRL
EAKIDKPSLV HWMCYKKTDD FFTLWIDLNM FMPIGIDCWI DNIRVVYNRT SRKTSNSAGV
TVRVPGFGQT YSVEFLDNNK LSGYFHTMVT HLVNIGYVRN QTVRAAPYDW RVAPNEQEEY
FTRLKNLLEE MYYQYQQPVY ILGHSMGSNY VLYFLLQQTQ AWKDRYIKGF ISLGAPWGGA
VKPLRVLASG ENDGIPLVSN IKIREEQRMT TTNPWMLPFE EAWPADHVFI STPSFNYTHQ
DYHRFFKDID FEDGWFMWED TRNLTAGLPP PGVETYCFYG VGLPTPVTYI YDDQFPDSDP
IDYVYADGDD TVESVSMGLC KRWVGKQQQP VHIKEFKAMP HLEMVFNSKV LSVVQSILEG
KYKEDDSTMH ETDERPIDSP QDLTQPVQGP HL
//
