ID A0A3P8Y2E8_ESOLU Unreviewed; 175 AA.
AC A0A3P8Y2E8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Glucagon family neuropeptides {ECO:0000313|Ensembl:ENSELUP00000010836.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000010836.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000010836.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000010836.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR RefSeq; XP_010902209.1; XM_010903907.2.
DR AlphaFoldDB; A0A3P8Y2E8; -.
DR STRING; 8010.ENSELUP00000010836; -.
DR Ensembl; ENSELUT00000001485.2; ENSELUP00000010836.1; ENSELUG00000011282.2.
DR GeneID; 105030196; -.
DR KEGG; els:105030196; -.
DR GeneTree; ENSGT00950000183154; -.
DR InParanoid; A0A3P8Y2E8; -.
DR OMA; VRNKGPP; -.
DR OrthoDB; 3925933at2759; -.
DR Proteomes; UP000265140; LG03.
DR Bgee; ENSELUG00000011282; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF1; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..175
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018182117"
FT DOMAIN 131..153
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 175 AA; 20338 MW; 63443C0082BDBFFD CRC64;
MARCNPSTLA LLVYGILMHY SVHCSPIGLS YPKIRLQNDA YDEEGNTLPD LSFDHDQMSI
RSPPSLADNV YTLYYPPEKR TERHAEEEVD RALREILGQL TARQYLTSLM TIRVGEDSSM
EDETQPLSKR HSDGIFTDSY SRYRKQMAVK KYLAAVLGRR YRQRVRNKGR RLTYL
//
