ID A0A3P8Y2I9_ESOLU Unreviewed; 427 AA.
AC A0A3P8Y2I9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Saccharopine dehydrogenase-like oxidoreductase {ECO:0000256|ARBA:ARBA00039852};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000010330.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000010330.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000010330.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
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DR RefSeq; XP_010898912.1; XM_010900610.3.
DR AlphaFoldDB; A0A3P8Y2I9; -.
DR Ensembl; ENSELUT00000002329.2; ENSELUP00000010330.2; ENSELUG00000000398.2.
DR GeneID; 105028104; -.
DR KEGG; els:105028104; -.
DR GeneTree; ENSGT00390000004799; -.
DR OrthoDB; 5479972at2759; -.
DR Proteomes; UP000265140; LG18.
DR Bgee; ENSELUG00000000398; Expressed in ovary and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 275..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..150
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 427 AA; 46793 MW; 2DF10BCC0DB77E11 CRC64;
MATVISNRPY HIIVFGASGF TGQFVVEEVA RNAKEGPSGS MKWALAGRSR HRLEGVLEQA
ADSLNKPELR IEVDIIVADV SDADSLAIMC QQGLVVLNCV GPYRFYGEPV VKACIENGAH
CIDICGEPQF LEGMQLEYHS KAMVSGVYVI GSCGFDSIPA DMGILYTKDH FKGTLTAVES
FLTIHTGPEG GCAHDSTWQS AIYGFADSGS LRKLRKKFGH QPLPVVGAPF KKRGCLFFSK
EINQYAIPFM GSDRSVVKRS QRFLYEDQKA TPVQYTAYVG VGGVWSLIKL FCGGLIFWFL
GKFRLGRKLL ITFPEIFSFG MFTKSGPSRK QMEGTSFRLT FFGEGYAEGT EPSQGRPNAR
ICTQIHGAEP GYVATSVTMV QAAITVLNEP QFLPVKGGVY SPGAVFAKTT LIHRLNKHGL
VFSVLRF
//
