ID   A0A3P8Y3H2_ESOLU        Unreviewed;       850 AA.
AC   A0A3P8Y3H2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=SEFIR domain-containing protein {ECO:0000259|PROSITE:PS51534};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000011218.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000011218.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000011218.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   AlphaFoldDB; A0A3P8Y3H2; -.
DR   Ensembl; ENSELUT00000000839.2; ENSELUP00000011218.2; ENSELUG00000011756.2.
DR   GeneTree; ENSGT00940000159018; -.
DR   InParanoid; A0A3P8Y3H2; -.
DR   OMA; EPGRIHQ; -.
DR   Proteomes; UP000265140; LG14.
DR   Bgee; ENSELUG00000011756; Expressed in stomach and 14 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030368; F:interleukin-17 receptor activity; IEA:InterPro.
DR   Gene3D; 3.40.50.11530; -; 1.
DR   Gene3D; 2.60.40.2160; Interleukin-17 receptor A/B, fibronectin-III-like domain 1; 1.
DR   Gene3D; 2.60.40.2150; Interleukin-17 receptor A/B, fibronectin-III-like domain 2; 1.
DR   InterPro; IPR039465; IL-17_rcpt-like.
DR   InterPro; IPR032356; IL17R_fnIII_D1.
DR   InterPro; IPR038683; IL17RA/B_FnIII-like_1_sf.
DR   InterPro; IPR043046; IL17RA/B_FnIII-like_2_sf.
DR   InterPro; IPR013568; SEFIR_dom.
DR   PANTHER; PTHR15583; INTERLEUKIN-17 RECEPTOR; 1.
DR   PANTHER; PTHR15583:SF13; INTERLEUKIN-17 RECEPTOR A; 1.
DR   Pfam; PF16556; IL17R_fnIII_D1; 1.
DR   Pfam; PF16578; IL17R_fnIII_D2; 1.
DR   Pfam; PF08357; SEFIR; 1.
DR   PROSITE; PS51534; SEFIR; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          324..480
FT                   /note="SEFIR"
FT                   /evidence="ECO:0000259|PROSITE:PS51534"
FT   REGION          690..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          725..751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          794..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   850 AA;  95205 MW;  3A9EBBC51230B3B5 CRC64;
     YSLFLSSPSL SSTCPSLHLP SNCHDKGWLI HRDYTPSDPV NLEVGVDTRE DEHGHLLPVL
     VARWKVKDDG STHFLEGTLL HVLMEATNQY ICVQYKFLNK ITMRNPADEM WSFSLDRVVV
     EPGLSYVVSV SNLPQPNLYY SFSNIFKVVT VPDCKDPRIR KTRVCLETGS LWTPNTTLER
     STAPHGRSIL TVGFNADQQA QKYSITLDCS NDRHRHDVNQ GNQTWLSVQF DLDVWPRTCC
     YFDVEIQPFF DLCSNDCVRR RKTFNICGAP MTVSPPVCPS PEIYIAIIVT TVLISCGLFC
     FLFYKLRRRP RGGVHPPPAP PRVPPRVLVI YSQDHPLYRK IVLKLCAFLQ AKCGTDVVLD
     LLDTAWLGTV GRLPWLEWQR QQISRSSDKI LVLCSRGVQA KWQAMCGQGR VTLREDLRSP
     IDDMLTPALN LFLPDMLRAA ALGKYVVAYF EDISSESDVP SVFDIAVKYK LMKNFEELCF
     RILNREKYAP GQVCHIEGIR EDEYVHCQSG KELRDAIEAF QTFQQENPDW FEQECVDVEA
     EEEVVAVTEY DALLEQPTAP VVECVPEYRD GPPIYVCGVD VHEGCRGVQV LSAEVNLGGK
     LTREAAFSRS PFYLPDRNGR SVLELLPRVN SESPGVCLSY PFMKPLPGVT IPGLNPHTPE
     RLACDLSDLA SEPPLARGNC LSLQDRMGTA SHSPVEIQEE SYAPSSGQPS ADTLGQLMSL
     QLSLSGISAD PGPRFTQNGS QSQQPVENNL SIPTDQSQLS FTSIQVTPPV SVGKQIQYLP
     PQPEISYSHP VEVREGQSVV EAPEKRPVSG SDQGYISRNS IQQDSPIEES IEDTLMALTR
     LQQALYYNCP
//