ID A0A3P8Y3T0_ESOLU Unreviewed; 608 AA.
AC A0A3P8Y3T0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Galactosidase, beta 1-like {ECO:0000313|Ensembl:ENSELUP00000010334.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000010334.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000010334.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000010334.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR AlphaFoldDB; A0A3P8Y3T0; -.
DR STRING; 8010.ENSELUP00000010334; -.
DR Ensembl; ENSELUT00000002321.2; ENSELUP00000010334.2; ENSELUG00000010822.2.
DR GeneTree; ENSGT00950000182942; -.
DR OrthoDB; 5489808at2759; -.
DR Proteomes; UP000265140; LG20.
DR Bgee; ENSELUG00000010822; Expressed in nose and 15 other cell types or tissues.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR PANTHER; PTHR23421:SF50; BETA-GALACTOSIDASE-1-LIKE PROTEIN; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 26..328
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 375..487
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 516..574
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 158
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 238
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 608 AA; 68928 MW; 57E36F7287C2D93D CRC64;
RQFSYLSLLV FGARSFSIDY KNNCFEKDGK PFQYISGSMH YSRVPHYYWK DRLQKMYMRL
NAQGVYNFSG HRDLEHFLDL ANQTGLLVIL RPGPYICAEW EMGGLPAWLL QKPNIVLRSA
DTDYLGAVNS WMAVLLPKMK RWLYTNGGNI ISVQVENEYG SYYACDYNYM RHLRTLFQLF
LGENTVLFTT DGNTDKEMTC GSLEGMYATI DFGTDTKISQ AFSRQRRFEP RGPLVNSEFY
TGWLDHWGDQ HAEVDTQKVS TMLGEMLSMG ASVNMYMFEG GTNFGYWNGA DHDNRFRSVV
TSYDYNAPLS EAGDPTEKLL TIQDTIRKFR EIPEGPMPPA SSKMAYGFVT LTMVGELNRL
LDTLCPQGPV KSQYPLSFEE MKQFYGFMLY RTKLPRDLPE NTALISPLNG VRDRAYVSVN
GVFQGILERD VTLVMNITGK QGDQIDVLVE NMGRVNFGSK INDRKGLLTH LILGMDVLKD
WLIFPLNIDE AIASGWPQSG MRRSTPTPIR GPSTGPVFYQ GTLAPNGLAW DTFLRLTDWT
KGQVWINGVN LGRYWPKRGP QQTLYVPGPL LSPTQPNNIT VLELEGAPPH TRVVFLDRPQ
LSSTASGT
//
