ID A0A3P8Y416_ESOLU Unreviewed; 399 AA.
AC A0A3P8Y416;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Sorting nexin family member 21 {ECO:0000313|Ensembl:ENSELUP00000010419.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000010419.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000010419.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000010419.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_010898306.1; XM_010900004.3.
DR AlphaFoldDB; A0A3P8Y416; -.
DR STRING; 8010.ENSELUP00000010419; -.
DR Ensembl; ENSELUT00000002182.2; ENSELUP00000010419.2; ENSELUG00000010899.2.
DR GeneID; 105027759; -.
DR GeneTree; ENSGT00530000063759; -.
DR InParanoid; A0A3P8Y416; -.
DR OMA; DQMERVC; -.
DR OrthoDB; 2916619at2759; -.
DR Proteomes; UP000265140; LG12.
DR Bgee; ENSELUG00000010899; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR039937; SNX20/SNX21.
DR PANTHER; PTHR20939; SORTING NEXIN 20, 21; 1.
DR PANTHER; PTHR20939:SF10; SORTING NEXIN-21; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 4: Predicted;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 123..240
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 22..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 45574 MW; 7F17B58964471DCA CRC64;
MASKLLDRLR RTLFKEGEAV FKEPTDVTED SFPESSELED DTECVSERLG GTLCFDGENV
LESEDPGEAS GLDSDSDFLG ESVEDGFGST ETSPVGQSLG GSSLLTHQLQ ENWRSMRSRS
VPEKLLFEVT DASVVQEGSS KYVLYTIHVI QSGMFDKSPA VITRRYSDFE RLHNRLRRRH
GDDMERVYFP RKKLRKNFVA ETIAKRSRAF EQYLTHMHSL AELRRSPTFL EFFYLGDLQA
GQMLMRVGHY QEALGPLLNG LRLQEKLGCE QQGKQQPQYQ QRTHWLFTLL ALVTSFQELE
QLGEAQEHCD RALRDLAPSQ DALLQHRFHP LLIPLLQINV RLSWKISRDK RRWEVLLQEI
QNSGVDVGNQ PSLKEYLMKE ALVESEGDSK GKAKGDDTT
//
