ID A0A3P8Y422_ESOLU Unreviewed; 1452 AA.
AC A0A3P8Y422;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Homeobox protein cut-like {ECO:0000256|RuleBase:RU361129};
GN Name=CUX1 {ECO:0000313|Ensembl:ENSELUP00000011413.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000011413.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000011413.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000011413.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family.
CC {ECO:0000256|ARBA:ARBA00008190, ECO:0000256|RuleBase:RU361129}.
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DR Ensembl; ENSELUT00000000494.2; ENSELUP00000011413.2; ENSELUG00000012042.2.
DR GeneTree; ENSGT00940000159751; -.
DR Proteomes; UP000265140; LG07.
DR Bgee; ENSELUG00000012042; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 3.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR14043; CCAAT DISPLACEMENT PROTEIN-RELATED; 1.
DR PANTHER; PTHR14043:SF4; HOMEOBOX PROTEIN CUT-LIKE 1; 1.
DR Pfam; PF02376; CUT; 3.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 3.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 3.
DR PROSITE; PS51042; CUT; 3.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transcription {ECO:0000256|RuleBase:RU361129};
KW Transcription regulation {ECO:0000256|RuleBase:RU361129}.
FT DOMAIN 520..607
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 957..1044
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 1113..1200
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 1251..1311
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 1253..1312
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 169..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 223..324
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 365..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1079
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1452 AA; 158539 MW; C599063CDC0BED6E CRC64;
MAANAGSMFQ YWKCFDLQQL QRELDSTATA LANRQDESEQ SRKKLIDQSR EFKKNTPEDL
RKQVAPLLKG FQAEIDAVSR RSKESEAAFL NVYKRLIDIP DPVSALEAAQ QLQLKVQRMH
DIETENQKLR ETLEAYTQEI AEVKNHEVTI KALKEKIEEY EETLKNQAKE LGQEERRQSE
KKEEEKGQLR NIHAEDQRYV GGLPVPMLGK SENFTFLCPS QRAEVAEKEA EALREQLSSA
NKSLQLATQI QKAPDMEQAL EVLSRSSLEV ELSAKEREVM QLADDVQRLQ ASLADVRENS
ASQISQLEQQ LSTNESSLKR LEGKLLEQSD YEDVKKELRC VERSWFVFPG PTGVRERKVK
ESSEGSQRLP ATPMGTNMQG SPPPPSSQHL LRTSSVGSSD TAPVTAANGT HHFSPTGGGL
GGQDFFSPSS LASAGNTYPL AGKVALNSLL QRQLMQTFYS KALQDSVSAS GQALLFSPAH
YPTPNSLSAS PLPPHQSHQP STGSPDVNGL APSPSQSEGT GSVSEGEDMD TSEIARQVKE
QLIKHNIGQR IFGHYVLGLS QGSVSEILAR PKPWNKLTIR GKEPFHKMRQ FLSDEQNILA
LRSIQGRQRE NPGQNLNRVF QEVPKRRTGS EGSSRPGNIT TRIRTLESGS DEAIKSILEQ
AKRELQVQKA DGVEDRQRRQ AGYPRGMGNY FAKYAQSLRL VDAPQPPCSS SGGGVSSGGS
SSSDETIRSI LEQARREMEA QQAALEPILK ASSMGPSDLA LLSPKLLGTP TLPASFSPLA
LSLKKPSVPP SSSPSSLLDF HSTVVKKESG EVAVGEGGGG SLTEGGPKQG RGSWRDQWWS
SMHPGGRGVT ANVSEDTRSQ EDSKEKPPRL GSSSSALAPF SSVSSLDYWK DWPRAESPYS
QAGSEPGGGC NTQGPSRADT PQSSPSPLSL SLGPLGSLLN PGAKQAKPVV APLTPEQYEF
YMYQEVDTAE LTQQVKDKLA KNGICQRVFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE
PFIRMQLWLN GELGQNVLPL QGQPQENTPK TSASCSPAPE SPLSSAEESV KSLGDQGSGG
GVSQVPPREL SEPSESQPGT PLPVPGHSGL SIQEMVAMSP ELDTYVITKK VKEVLTDNNL
GQRLFGETIL GLTQGSVSDL LARPKPWHKL SLKGREPFVR MQLWLQDPRN VEKLMDMKRM
EKKAYMKRRH SSVSESQTVD SGGLSGGDFS QGGSPQHGLG HHLHQQQPPQ QHLKKPRVVL
APEEKEALKR AYQQKPYPSP KTIEELASQL NLKTSTVINW FHNYRSRIRR ELFIEEIQRG
EGGEGGSPST RAGKASEGDS CDGTESDGTV ESTRPSQDPH PPSEGEGGSD HRDEGTTSAT
SSTAAGTSSH HKGGALDSLF SFPESGHVSS VATTARNPRD SSLRKKKAAN LNNIIHRLEK
AASKDEPHEW EF
//