GenomeNet

Database: UniProt
Entry: A0A3P8Y422_ESOLU
LinkDB: A0A3P8Y422_ESOLU
Original site: A0A3P8Y422_ESOLU 
ID   A0A3P8Y422_ESOLU        Unreviewed;      1452 AA.
AC   A0A3P8Y422;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Homeobox protein cut-like {ECO:0000256|RuleBase:RU361129};
GN   Name=CUX1 {ECO:0000313|Ensembl:ENSELUP00000011413.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000011413.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000011413.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000011413.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the CUT homeobox family.
CC       {ECO:0000256|ARBA:ARBA00008190, ECO:0000256|RuleBase:RU361129}.
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DR   Ensembl; ENSELUT00000000494.2; ENSELUP00000011413.2; ENSELUG00000012042.2.
DR   GeneTree; ENSGT00940000159751; -.
DR   Proteomes; UP000265140; LG07.
DR   Bgee; ENSELUG00000012042; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 3.
DR   InterPro; IPR003350; CUT_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   PANTHER; PTHR14043; CCAAT DISPLACEMENT PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14043:SF4; HOMEOBOX PROTEIN CUT-LIKE 1; 1.
DR   Pfam; PF02376; CUT; 3.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM01109; CUT; 3.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 3.
DR   PROSITE; PS51042; CUT; 3.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Transcription {ECO:0000256|RuleBase:RU361129};
KW   Transcription regulation {ECO:0000256|RuleBase:RU361129}.
FT   DOMAIN          520..607
FT                   /note="CUT"
FT                   /evidence="ECO:0000259|PROSITE:PS51042"
FT   DOMAIN          957..1044
FT                   /note="CUT"
FT                   /evidence="ECO:0000259|PROSITE:PS51042"
FT   DOMAIN          1113..1200
FT                   /note="CUT"
FT                   /evidence="ECO:0000259|PROSITE:PS51042"
FT   DOMAIN          1251..1311
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        1253..1312
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          169..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          702..725
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          810..877
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          897..936
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1038..1108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1203..1255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1319..1402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1407..1426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          223..324
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        365..412
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..527
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        709..725
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        904..933
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1038..1079
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1215..1232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1342..1359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1374..1389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1452 AA;  158539 MW;  C599063CDC0BED6E CRC64;
     MAANAGSMFQ YWKCFDLQQL QRELDSTATA LANRQDESEQ SRKKLIDQSR EFKKNTPEDL
     RKQVAPLLKG FQAEIDAVSR RSKESEAAFL NVYKRLIDIP DPVSALEAAQ QLQLKVQRMH
     DIETENQKLR ETLEAYTQEI AEVKNHEVTI KALKEKIEEY EETLKNQAKE LGQEERRQSE
     KKEEEKGQLR NIHAEDQRYV GGLPVPMLGK SENFTFLCPS QRAEVAEKEA EALREQLSSA
     NKSLQLATQI QKAPDMEQAL EVLSRSSLEV ELSAKEREVM QLADDVQRLQ ASLADVRENS
     ASQISQLEQQ LSTNESSLKR LEGKLLEQSD YEDVKKELRC VERSWFVFPG PTGVRERKVK
     ESSEGSQRLP ATPMGTNMQG SPPPPSSQHL LRTSSVGSSD TAPVTAANGT HHFSPTGGGL
     GGQDFFSPSS LASAGNTYPL AGKVALNSLL QRQLMQTFYS KALQDSVSAS GQALLFSPAH
     YPTPNSLSAS PLPPHQSHQP STGSPDVNGL APSPSQSEGT GSVSEGEDMD TSEIARQVKE
     QLIKHNIGQR IFGHYVLGLS QGSVSEILAR PKPWNKLTIR GKEPFHKMRQ FLSDEQNILA
     LRSIQGRQRE NPGQNLNRVF QEVPKRRTGS EGSSRPGNIT TRIRTLESGS DEAIKSILEQ
     AKRELQVQKA DGVEDRQRRQ AGYPRGMGNY FAKYAQSLRL VDAPQPPCSS SGGGVSSGGS
     SSSDETIRSI LEQARREMEA QQAALEPILK ASSMGPSDLA LLSPKLLGTP TLPASFSPLA
     LSLKKPSVPP SSSPSSLLDF HSTVVKKESG EVAVGEGGGG SLTEGGPKQG RGSWRDQWWS
     SMHPGGRGVT ANVSEDTRSQ EDSKEKPPRL GSSSSALAPF SSVSSLDYWK DWPRAESPYS
     QAGSEPGGGC NTQGPSRADT PQSSPSPLSL SLGPLGSLLN PGAKQAKPVV APLTPEQYEF
     YMYQEVDTAE LTQQVKDKLA KNGICQRVFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE
     PFIRMQLWLN GELGQNVLPL QGQPQENTPK TSASCSPAPE SPLSSAEESV KSLGDQGSGG
     GVSQVPPREL SEPSESQPGT PLPVPGHSGL SIQEMVAMSP ELDTYVITKK VKEVLTDNNL
     GQRLFGETIL GLTQGSVSDL LARPKPWHKL SLKGREPFVR MQLWLQDPRN VEKLMDMKRM
     EKKAYMKRRH SSVSESQTVD SGGLSGGDFS QGGSPQHGLG HHLHQQQPPQ QHLKKPRVVL
     APEEKEALKR AYQQKPYPSP KTIEELASQL NLKTSTVINW FHNYRSRIRR ELFIEEIQRG
     EGGEGGSPST RAGKASEGDS CDGTESDGTV ESTRPSQDPH PPSEGEGGSD HRDEGTTSAT
     SSTAAGTSSH HKGGALDSLF SFPESGHVSS VATTARNPRD SSLRKKKAAN LNNIIHRLEK
     AASKDEPHEW EF
//
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