ID   A0A3P8Y4I9_ESOLU        Unreviewed;       909 AA.
AC   A0A3P8Y4I9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Importin-13 {ECO:0000256|ARBA:ARBA00016020};
GN   Name=IPO13 {ECO:0000313|Ensembl:ENSELUP00000011592.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000011592.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000011592.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000011592.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
CC       {ECO:0000256|ARBA:ARBA00011422}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the importin beta family.
CC       {ECO:0000256|ARBA:ARBA00007991}.
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DR   AlphaFoldDB; A0A3P8Y4I9; -.
DR   Ensembl; ENSELUT00000000201.2; ENSELUP00000011592.2; ENSELUG00000001498.2.
DR   GeneTree; ENSGT00530000063347; -.
DR   Proteomes; UP000265140; LG08.
DR   Bgee; ENSELUG00000001498; Expressed in brain and 14 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:UniProt.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040709; Importin_rep_1.
DR   InterPro; IPR040944; Importin_rep_2.
DR   InterPro; IPR040520; Importin_rep_3.
DR   PANTHER; PTHR12363:SF56; IMPORTIN-13; 1.
DR   PANTHER; PTHR12363; TRANSPORTIN 3 AND IMPORTIN 13; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF18773; Importin_rep; 1.
DR   Pfam; PF18786; Importin_rep_2; 2.
DR   Pfam; PF18806; Importin_rep_3; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          24..90
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REGION          635..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   909 AA;  101615 MW;  AC79CA2ED2869DE4 CRC64;
     AFSRLQAALH QLYYDPNIEN KNLAQKWLMQ AQVSPQAWQF SWALLSPDKV PEIQYFGASA
     LHTKISRYWS DIPSDQYETL KTQLFSQIAC FSSGSKMVLT RLCVALASLA LNTMPEAWPG
     AVPEMVRVFQ EEGGGVDGRA RCLALLELLT VLPEEFQTSR LPQYRKGQVR GALGREWGSV
     CPLLQQLLRR GDSPGAVKAR VLRCLSSWVL LDVPLSESEG LVEDCFTALP DPELFDTAVE
     AIVNAISQPD SQRYVNTLLK LVPQVLSLQD QLREAVQSGD METSHGICRI AVALGENHSR
     ALLEQVEHWQ GFLALVNMIM FCTGIPGHYP VNETTSSLTL TFWYTLQDDI MSFDSERQAV
     YLQVYRPVYF QLVDVLLHKA QFPSDQEYAT WSSDEKEQFR IYRVDISDTL MYVYEMLGAE
     LLSNLYEKLG RILTNTEPAS SWQHTEALLY GFQSIAETID VNYSDVIPGL IGLIPRININ
     NVQLADTVMF TIGALAEWLA DHPVMLSSVL PLVLQALGNP DLSVSSVSTL KKICRECKYD
     LPPYASNIVA VSQEVLIKQI HKTSQCMWLM QALGFLLSAL PVEEILRNLH SLITPYIQQL
     EKLADETPNP SNKLAIIHIL GLLSNLFTTL DISKQEDESG ESTAPPIKTA PPPPGPNPVV
     VVLQQVFALI QTVLSKWLND SQVVEAVCAI FEKSVKTLLH DFAPMVSQLS EMLGQMYSTI
     PQASALDLTR QMVHIFASET EHFPPIKALF ELVTSVTLSI FQQGRGSRVL SLKFPEAPTV
     KSTCLFFTEL LPHCSDVPPL ARVVQEDGKL LLQAVIEAIG GGSSRGLMDQ FAEVLFSLNK
     HCFSLLTMWL KEVLQSPGFP STRVTSEQKD TFTQQILRER VNKRRVKDIV KEFTLVCRGL
     HGTEYAADY
//