ID A0A3P8Y4M4_ESOLU Unreviewed; 1154 AA.
AC A0A3P8Y4M4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE AltName: Full=Slowpoke homolog {ECO:0000256|ARBA:ARBA00033447};
GN Name=KCNMA1 {ECO:0000313|Ensembl:ENSELUP00000011627.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000011627.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000011627.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000011627.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008648}.
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DR AlphaFoldDB; A0A3P8Y4M4; -.
DR Ensembl; ENSELUT00000000138.2; ENSELUP00000011627.2; ENSELUG00000012230.2.
DR GeneTree; ENSGT00940000154935; -.
DR OrthoDB; 2902976at2759; -.
DR Proteomes; UP000265140; LG06.
DR Bgee; ENSELUG00000012230; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF41; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..357
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 515..602
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 968..1091
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 670..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 129786 MW; 2A13B007900FE261 CRC64;
MLVTEHGNLS QGIGSLRIMS KGKHNYYPDS PSVRVSKMDV IIPFSPDVPC DSNGQRMWWA
FLASSMVTFF GGLFIILLWR TLNYMWTVCC HCNAKKKGSQ RGQNPVSHGD GIKHTKETVA
ALSEVGWMTS VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSD PIESCQNFYK
DFTLQIDMAF NIFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL
RFLRALRLIQ FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF
QNSQSLSYWE CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA RYVPEIAALI
LNRKKYGGSY NSTRGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE
LEALFKRHFT QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS
IKNYHPKIRI ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAQGLSTM
LANLFSMRSF IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPTICEL CYVKLKLLLI
AIEYKSDIRE SSTLINPGNH VKMQEGTLGF FIASDAKEVK RALFYCKACH DDITDPKRIK
KCGCKRVEEE QHSTLSPKRK QRNGNTRNSP HGSPKMMRHD PLLMPGNEQI ENMDVNVKKY
DSTGMFHWCQ SKDIERVILT RSEAAMTVLS GHVVVCIFGD AKSALVGLRN LVMPLRASNF
HYHELKPIVF VGSLEYLKRE WETLHNFPKV SILPGTPLSR ADLRAVNINL CDMCVILSAN
QNNIDDASLQ DKECILASLN IKSMQFDDSI GVLQATSQGF TPPGMDRSSP ENSPAHGGLA
RQASITTGAN IPIITELVND SNVQFLDQDD DDDPDTELYL TQPFACGTAF AVSVLDSLMS
ATYFNDNILT LIRTLVTGGA TPELEGLLAE ENALRGGYST PQTLANRDRC RVAQLALYDG
PFADLGDGGC YGDLFCKALK TYNMLCFGIY RLRDAHLNTQ SHTSLCTKRY VITNPPYGFE
LVTSDLIFCL MQFDHNAGQS RASLSHSSHS SHTSSRKSVH SIPATNRTNR AKSRDLRDKQ
KYVPLQTRFP PTRA
//
