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Database: UniProt
Entry: A0A3P8Y7T4_ESOLU
LinkDB: A0A3P8Y7T4_ESOLU
Original site: A0A3P8Y7T4_ESOLU 
ID   A0A3P8Y7T4_ESOLU        Unreviewed;       797 AA.
AC   A0A3P8Y7T4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Cadherin 6 {ECO:0000313|Ensembl:ENSELUP00000012659.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000012659.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000012659.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000012659.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003318};
CC       Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003318}.
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DR   AlphaFoldDB; A0A3P8Y7T4; -.
DR   STRING; 8010.ENSELUP00000012659; -.
DR   Ensembl; ENSELUT00000021016.2; ENSELUP00000012659.2; ENSELUG00000012875.2.
DR   GeneTree; ENSGT00940000154673; -.
DR   InParanoid; A0A3P8Y7T4; -.
DR   OMA; NLAWHNI; -.
DR   OrthoDB; 3667774at2759; -.
DR   Proteomes; UP000265140; LG03.
DR   Bgee; ENSELUG00000012875; Expressed in embryo and 13 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0048890; P:lateral line ganglion development; IEA:Ensembl.
DR   GO; GO:0048793; P:pronephros development; IEA:Ensembl.
DR   GO; GO:0060042; P:retina morphogenesis in camera-type eye; IEA:Ensembl.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 5.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027:SF428; CADHERIN 6; 1.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..797
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5027746641"
FT   TRANSMEM        619..640
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          77..157
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          158..268
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          269..382
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          383..492
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          492..603
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          754..776
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        755..771
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   797 AA;  88045 MW;  448401625963976A CRC64;
     MRTCLLALLW ASLSHCVDAM FLTGRTGVET GREEMIGDGA REGKLLRRFK RGWMWNQFFL
     QEEYTGSDKQ YIGKLQSDMD KGDGTLKYIL TGDGAGDIFT IDESNGDLHA NKRLDREEKA
     FYTLRATVVN RNTGKKLEPE TEFIVKLHDI NDNEPKFAKE VYTASVPESS VIGTSVTQVT
     ATDADDSMYG NSAKLRYSIS QGHPYFSVDP DTGVIRTALG PGEMDREKRE HYQVVIEAKD
     MAGQRGGLTG TTAVNITLTD VNDNAPGFSQ NMYQFSVPES IKAGHPVGRI KAVDKDIGKN
     AEMSYSVVSG DGLDIFDVNT DRNTQEGVIT VLKPLDYEKT MSYTLEIQVQ NVQALHTHSQ
     GTLPTIATVR IDVEDVDEPP LFERASYLME VKEDAALGAV VGSVRAMDPD RTNSPVRSVG
     ATYSIDRRTD LDRHFNVHSG NGSIFITRPL DREEADWHNI SVIATEFNKP LQASRVPVYI
     RLLDVNDNAP MFASFYETFV CEKTKAGQKI QMVSAVDADD PVGGHKFFFS LDTEGVYRGN
     FTVRDNGDNT ASILTRRSSY NPLHKSVYLV PVVITDGDFP MQSSTGTLTV RVCTCDREGN
     MELCNAEAQT SSAGLSTGAL VAILLCVIIL LMIVVLFAAL KRQKKKEPLI ISKEDVRDNV
     VSYNDEGGGE EDTQAFDIGA LRNPEAMEES KQRRDIIPSD TLYPPLRRTA IPSQDNADVR
     EFINQRVVDN DSNPTAPPYD SLATYAYEGA GSVAESLSSL GSASSEGDQD YNYLSDWGPR
     FRKLADMYGA EDSDRDS
//
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