ID A0A3P8Y832_ESOLU Unreviewed; 806 AA.
AC A0A3P8Y832;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Kin of IRRE-like protein 1 {ECO:0000313|Ensembl:ENSELUP00000012215.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000012215.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000012215.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000012215.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_010892852.1; XM_010894550.1.
DR AlphaFoldDB; A0A3P8Y832; -.
DR Ensembl; ENSELUT00000038003.2; ENSELUP00000012215.1; ENSELUG00000012509.2.
DR GeneID; 105024550; -.
DR GeneTree; ENSGT00940000155795; -.
DR OrthoDB; 5362512at2759; -.
DR Proteomes; UP000265140; LG03.
DR Bgee; ENSELUG00000012509; Expressed in stomach and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05898; IgI_5_KIRREL3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF14; KIN OF IRRE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..806
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017997658"
FT TRANSMEM 496..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..113
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 121..214
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 221..297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 306..386
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 390..492
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 628..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 87677 MW; 40FB05D396C51997 CRC64;
MLRLWIITLA ISFNKVWTVR FSQEPADQSV VLGDTVVLSC VVFNYTGIVQ WTKDGLALGV
GEGLRAWPRY RVLRVIDMGQ YNLEISAAEL SDDSLYECQA TEAALRSRRA KLTVLIPPDD
PVVAGFPEIL LIGDVPYNLS CVTRGAKPLA VIEWERDGVP LEGAISTTEV LPDRKRVTTK
SLLPIIPKDY DTGHNFTCVA RNKAVPLGKN TTVTLNVQHS PKVNLSMHPR SVLEGERITF
NCQAFANPPI MGFRWAKGGV LLAGARESVL MTTADHSFHT EPVSCSVFNA VGHTNVSIVV
DVHYGPILKV EPRPVTVDVD SEAKLKCKWS GNPPLTLTWT KKGSSMVLSN NEELVLKSVS
QADAGQYVCK AIVPRIGVGE REVTLTVNGP PIISSESVQY AVRGKRGEVK CFIASTPPPD
KIVWAWKENV WEKEKGTLLE RYTVEQSKPN SPGGAVLSTL TINNVMESDF HSPYNCTAWN
AFGPGTMIIT LEENEIFPVG IIVAGIVGSS ILLLGFLLAL AFFLYRQRKG SRRGVTLGKP
DIKVETVNKE THSLEEETGN VSTATRMVKA MYSPFKDDVD LKQDLRSELD TREEYELKDP
TNGYYNVRAT THDDARASSR SVLYQGEFRS NPGGGATGAA PTGPAGGPGG VMAAGGVPGS
RMGCYDPRPP SRMSHASYAQ FNTFTRTGQS QGPPNSSHPS HPAAQTGDFL GECSPLDANT
KLTYDNFGYP AYRMGFAPPL EGGPAYEMYS TGQGVGPRPV QGPIEGQGQG PETVVGKYGT
STRFSYSSPP GTEYNQRHTQ RMQTHV
//
