ID A0A3P8Y8C3_ESOLU Unreviewed; 515 AA.
AC A0A3P8Y8C3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Epidermal growth factor receptor kinase substrate 8-like protein 1 {ECO:0000313|Ensembl:ENSELUP00000012854.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000012854.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000012854.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000012854.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8Y8C3; -.
DR STRING; 8010.ENSELUP00000012854; -.
DR Ensembl; ENSELUT00000038272.2; ENSELUP00000012854.2; ENSELUG00000013057.2.
DR GeneTree; ENSGT00940000158125; -.
DR InParanoid; A0A3P8Y8C3; -.
DR OMA; KRWWKCQ; -.
DR Proteomes; UP000265140; LG11.
DR Bgee; ENSELUG00000013057; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR PANTHER; PTHR12287:SF25; ZGC:113583-RELATED; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 274..333
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 57550 MW; BF2B55E31C470010 CRC64;
MSGTPPPVRP RNASGIRVMP HNRHRHSHDL PENVKVNGSS SVPKPTSSVN AEREVEILNH
CFDDIERFMG RLQQTAEAQS ILNQNGTRKK SRKSKKKKEQ DDDLLALKAS CPADEEFVDI
FQKIKYSFSL LDRLKSSITD PSSEELLHHI FIPLDLMVKT TGGPEMGGIV ISPALTSGAV
SLLQKHLTDK EKELWTSLGP YWTLHRSQLD ESVPPYTPVF LDGWKPDHFD LGGQLWGDPV
ESQHKQDALP NTAAKPLDQT NEGHPRDGSE LPPEGERMFT CSYDFVARNS SELSVLQGET
LEVIESSKRW WKCRNRFDQI GFVPFNILEP LAGGGDESDS SKVLVQSKKE PLAPLKQFSY
SFSGPEGPNP TAVPRRHPSM NMEVRDQGFM ANNELLQRLA NGRPASVRPL VIPRTTDTLA
PLDFHSPPAE VEDWLRGKGF TESTVTLLGR LSGAELFALN KADLRMFSPD EGARVYSQMM
VQKALLEDVH KATELETMME KQKQKVDSEL ESGTL
//
