ID A0A3P8Y8W7_ESOLU Unreviewed; 697 AA.
AC A0A3P8Y8W7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit beta {ECO:0000313|Ensembl:ENSELUP00000012259.2};
GN Name=PIK3R2 {ECO:0000313|Ensembl:ENSELUP00000012259.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000012259.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000012259.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000012259.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR AlphaFoldDB; A0A3P8Y8W7; -.
DR STRING; 8010.ENSELUP00000012259; -.
DR Ensembl; ENSELUT00000020503.2; ENSELUP00000012259.2; ENSELUG00000012532.2.
DR GeneTree; ENSGT00940000157050; -.
DR Proteomes; UP000265140; LG08.
DR Bgee; ENSELUG00000012532; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12926; iSH2_PIK3R2; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..79
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 80..273
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 306..401
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 598..690
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 90..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 79868 MW; D20E3C39C04B90D3 CRC64;
MAVEGFQFRA LYVYNRDLEE DLDLQPGDIL TVSKASLASL GLKDGDEEHP ARMGWIVGIN
ERTKQRGDFP GTYVQYVGTV KMFVMPNQPR QQRPLPAVPR PQPPPSQQGK TSALHCLFPV
TQNHFQRNGC LTEAFMWGFS DLPESEMGQH DVRGLTEALL GFLRDLPSPV IPESVYPSLR
SALNEGLSVE DSGRRLLKEL VPPAVPAASL LTLQYLLRHL DRVAQRAECN GLDPASLSLL
FTPLLFSAGS EEDHLFSVQV LERLLVARAW ELEQMPPALP PKPSKTKAVA SSVISGDGGK
MADAEWYWGD ISREEVNEKM RDTPDGTFLV RDASSKVQGE YTLTLRKGGN NKLIKIFHRG
GKYGFSEPLT FSSVVELILH YHHESLAQYN PKLDSRLLYP VSKFQQDQMV KEDNVEAVGE
QLKVYHEQYQ EKSQAYDILY EEYTRTSQEL QMKRTAIEAF NETIKIFEEQ CQTQERYSKE
YMEKFQREGN SKEMERIQSN SNKLKSRVTE IHDSKRRLEQ DLKEEAADNR EIDKKMNSLK
PDLMQLRKIR DQYLVWLNQK GTRQRKINEW LGIKNDIEDV YSLVDEEEDL PHHDERTWYV
GNIKRGQAEE LLRGKDDGTF LIRDSQSQKG SYACSVVDIK HCVIFKTSTG YGFAEPYNLY
ASLRELVLHY RHTSLVQHND SLNVTLAFPV LTQQQTR
//
