ID A0A3P8Y949_ESOLU Unreviewed; 815 AA.
AC A0A3P8Y949;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Exosome component 10 {ECO:0000313|Ensembl:ENSELUP00000012591.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000012591.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000012591.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000012591.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR AlphaFoldDB; A0A3P8Y949; -.
DR Ensembl; ENSELUT00000020918.2; ENSELUP00000012591.2; ENSELUG00000012870.2.
DR GeneTree; ENSGT00390000015408; -.
DR Proteomes; UP000265140; LG12.
DR Bgee; ENSELUG00000012870; Expressed in muscle tissue and 14 other cell types or tissues.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 500..580
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 93374 MW; ABFAEC78AE1FDBCB CRC64;
MDSSNSSKQN NNPSPNDDPA DEGNEFCPGF KDVDAFVKYG LGTVVAATKS SASLPQVGDE
YDFYRSFPGF QEFCETQGDT MLHCMSQIMK YHGCRAQMRD RNKLTGLEER YDLVVDANDV
ILEKVGILLD DTAGVNRSQQ PVMPAGFQPP KIVVSSWNRK GGDSGSSSET FRLLHAKNIT
RPQLKFREKV DNSNTPFVPK IFIKPNAMKS LPSYFTNKQI RKERPEDLDV PAALADFIHQ
QRTQEHVEDM FAHPYQYELD HLVFSENQLS KPEPQMYKPL AETKCSFIDN VEDLVAVNEK
LTKTTEFAVD LEHHSYRSFL GITCLMQIST REEDFIIDTL DLRSEMYILN EAFTDPNIVK
VFHGADSDIE WLQKDLGLYI VNMFDTHQAS RVLNLGRHSL DHLLKQFCNV DSDKRYQLAD
WRIRPLPEEM LHYARADTHY LLYVYDRLRV DLWEMGNGQP ALLQTVWQKS KDISLKKYMK
PLFTENSYMD LLRKQKKAFN TQQLAAFRLL YGWRDKLARQ EDESTGYVLP NHMMIKISEV
LPKEPQGIIA CCNPVPPLVR QQVNELHLLV QQAREMPLLK VRDPEMPLFG PHDTSRVPES
EFPSFSPKGK LFTNNVLCLV LLVLKDKDTV KDSGHLTVAQ QKAYIIVDSF QNPFRMYLPS
TEIHISKNAK FDPSTKIYEI SNRWKLQSIE QQHKELEAKK KEKEDAKEST NTGAKKRERV
ASGTGESNPK PNKKLMKAAD KQEECIPPAV FKPFDYSQSD FKVFAGTQPH ALVHNLFVND
ILLHLHTRPS FFCGPKSNAC AGNRSMSFFG GKSER
//
