ID A0A3P8YAR4_ESOLU Unreviewed; 641 AA.
AC A0A3P8YAR4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Notch NODP domain-containing protein {ECO:0000259|Pfam:PF07684};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000012910.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000012910.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000012910.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8YAR4; -.
DR STRING; 8010.ENSELUP00000012910; -.
DR Ensembl; ENSELUT00000021317.2; ENSELUP00000012910.2; ENSELUG00000013110.2.
DR GeneTree; ENSGT01000000219459; -.
DR InParanoid; A0A3P8YAR4; -.
DR OMA; TRSALHW; -.
DR Proteomes; UP000265140; LG20.
DR Bgee; ENSELUG00000013110; Expressed in spleen and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24184:SF11; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24184; SI:CH211-189E2.2; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF07684; NODP; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..61
FT /note="Notch NODP"
FT /evidence="ECO:0000259|Pfam:PF07684"
FT REPEAT 324..356
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 357..389
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 142..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 71019 MW; 3528E9EB2016497F CRC64;
MFSLNLFSFV NMDVLSPSLL ASSLLFLQVD NRPCSRLPSA CFPSAIEAAH FLRAATSSSR
TAVASHPELN AIISLRGVKE EIGTREEDQD ETNSAIPPWL WAVIGVATGL VLALVFVVVL
VIRRVRGRGA EREGVGGERI RHRSIVTDND SRASGAKAWA QHTPHREHRG VTGREKDRNG
VRKKKKAKEA ERKRRKEPLG EDAIRLRPLK KDLDIGSDTD FTQSSMEDIN RSICDHRTQE
QKHYGSPPNH PQTPIQPLLL APPRGWERNA VPSPHHRTPN QSAPVQWCGP DGSVVLIRAV
RSGLDRVVLE LLRAGVPVNN TDHTGRSALH WACSVNHLSL TRTLIRYGAA VDLQDNKGET
ALFLSALHGC YDTARFLLLN GANQDLPDRR GRRAIHVAQE SMHHQVLELL LAHRAQRGPI
HMEQASDMLW DERALLYGQC VNSPGLPGRS ASFSGTVGHR DMASPTQSDW SMGRVQCPSP
QNWRPQVNQS VTALVTPRIM GRSPRPISTL QEVTSEDEDR ERTHEVPRAV TPHFLLPQPA
PRQRSFSCTQ NALQRRSSAH QPEPNYVALS EKISNEPVDR VIVAPPTEVP TQTECRSVVN
NGTANPSRAE PENEAVNSKN AIQKTRGEKQ NNVPDSNQTA L
//
