ID A0A3P8YAZ6_ESOLU Unreviewed; 1178 AA.
AC A0A3P8YAZ6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=PDZ domain containing 8 {ECO:0000313|Ensembl:ENSELUP00000013767.1};
GN Name=PDZD8 {ECO:0000313|Ensembl:ENSELUP00000013767.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000013767.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000013767.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000013767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010890558.1; XM_010892256.3.
DR AlphaFoldDB; A0A3P8YAZ6; -.
DR STRING; 8010.ENSELUP00000013767; -.
DR Ensembl; ENSELUT00000022395.2; ENSELUP00000013767.1; ENSELUG00000013841.2.
DR GeneID; 105023228; -.
DR GeneTree; ENSGT00390000017746; -.
DR InParanoid; A0A3P8YAZ6; -.
DR OMA; HIALECM; -.
DR OrthoDB; 3681901at2759; -.
DR Proteomes; UP000265140; LG06.
DR Bgee; ENSELUG00000013841; Expressed in mesonephros and 15 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:InterPro.
DR GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:InterPro.
DR CDD; cd20825; C1_PDZD8; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd21674; SMP_PDZD8; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039275; PDZD8.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR031468; SMP_LBD.
DR PANTHER; PTHR21519; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21519:SF1; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51847; SMP; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transport {ECO:0000256|ARBA:ARBA00023055};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 108..298
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 372..455
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 877..928
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 56..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1050..1077
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 56..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..611
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..681
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 130489 MW; 9247ECA6ECEF6BF1 CRC64;
MIYLIVISAL SGAVITLVLQ FLLLYRRSPE PIARTVQYVK AVPDPALKDY FNNQHAESGQ
QQQDNTASAA SKQQDSISTR QQEVSVTSSS PKQQPPPPYQ SEPLHSSKPE TCNFLNAIFL
FLFRELRDTP VVRHWLTKKI KVEFEELLQT KTAGRLLEGL SLRDISLGNS LPVFKTAKLM
KPVSLNEDGM PEELNFEVDL EYNGGFHLAI DVDLVFGKSA YLFVKMTRVV GRLKLQFTRV
PFTHWSFTFL EDPLIDFEVK SQFEGRPLPQ LTSIIVNQLK RVIKKKHTLP NYKIRYKPFF
PFQVQPPIGS SSCEFDLSIQ ASGLVEGRLR VTLVECSRLF ILGSYDRETY VHCTFELSSH
EWKEKTRSSI KTTELIKGPS GSVGMTFRHV PASEGDAVHV SIETITPNSP AALADLQRGD
RLIAIGGVNV TSSVQVPKLL KQAGERVLVL YERPLRHQNA TVGLGAQQDG LGHIEEPSFI
PPQAGYEEDP APITTLADIS DSKDMDSEFE ELIVDPKPSS LSSSAEARED FLSVNQSPKR
TVANLASKPL GSISPILNRK LNLAGLQSPA RPPPTPKPSP HKSAESGEGP QRPTVPPPPP
PTRPPVPPRP QIKLTSACSE TQSLLEGSES LAMADKTPEK TQTYSGGING DKNSAVTTPV
KQPEPKPVVK PPEPCEELPV APPAPNKQDL ARDKVSESSI NTRDSTEDQS TWESSEIMFR
NRMAHWGHAS VVFEVESNHK YLNVALWCKD PFKLGSLLCL GHVSLKLEHI ALECLSTSSS
EYQSTFRLEA PEPRASVSRT ALRSLSTHKG FNEKLCYGDV TLNFSYLADG DSDMCGGLSE
LERKASVPDE ELREREHVSC IPREDLAYSG IQLVEVRHNF QDTQFQNPTW CEYCKKKVWT
KAASQCMICS YVCHKKCQEK CLAEYPLCVA ATDRRSADPE AKSTINRATT GLSRHIINTG
TRLLNLRQVP KSRLAEQAAD VVPDAVHTPD ISDNESSDTE TYTGASPSKH ATGGSNKLVR
REGGLDDSVF IAVKEIGRDL YRGLPTDERS QKLELMLDKL QQEIDQELEH NNALVLEEKE
TGDARRKALI ASALAKSGER LQALTLLMIH YRAGIEDLES VDSTSTSPSE PQGLKTKGVA
LEEALLEPEV YDSDICNPVE AQQSEDITEE QICVEALH
//