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Database: UniProt
Entry: A0A3P8YAZ6_ESOLU
LinkDB: A0A3P8YAZ6_ESOLU
Original site: A0A3P8YAZ6_ESOLU 
ID   A0A3P8YAZ6_ESOLU        Unreviewed;      1178 AA.
AC   A0A3P8YAZ6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=PDZ domain containing 8 {ECO:0000313|Ensembl:ENSELUP00000013767.1};
GN   Name=PDZD8 {ECO:0000313|Ensembl:ENSELUP00000013767.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000013767.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000013767.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000013767.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_010890558.1; XM_010892256.3.
DR   AlphaFoldDB; A0A3P8YAZ6; -.
DR   STRING; 8010.ENSELUP00000013767; -.
DR   Ensembl; ENSELUT00000022395.2; ENSELUP00000013767.1; ENSELUG00000013841.2.
DR   GeneID; 105023228; -.
DR   GeneTree; ENSGT00390000017746; -.
DR   InParanoid; A0A3P8YAZ6; -.
DR   OMA; HIALECM; -.
DR   OrthoDB; 3681901at2759; -.
DR   Proteomes; UP000265140; LG06.
DR   Bgee; ENSELUG00000013841; Expressed in mesonephros and 15 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProt.
DR   GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:InterPro.
DR   GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:InterPro.
DR   CDD; cd20825; C1_PDZD8; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd21674; SMP_PDZD8; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR039275; PDZD8.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR031468; SMP_LBD.
DR   PANTHER; PTHR21519; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR   PANTHER; PTHR21519:SF1; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS51847; SMP; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Transport {ECO:0000256|ARBA:ARBA00023055};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          108..298
FT                   /note="SMP-LTD"
FT                   /evidence="ECO:0000259|PROSITE:PS51847"
FT   DOMAIN          372..455
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          877..928
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   REGION          56..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          565..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          977..1020
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1050..1077
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        56..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        591..611
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..628
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        635..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..681
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        990..1013
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1178 AA;  130489 MW;  9247ECA6ECEF6BF1 CRC64;
     MIYLIVISAL SGAVITLVLQ FLLLYRRSPE PIARTVQYVK AVPDPALKDY FNNQHAESGQ
     QQQDNTASAA SKQQDSISTR QQEVSVTSSS PKQQPPPPYQ SEPLHSSKPE TCNFLNAIFL
     FLFRELRDTP VVRHWLTKKI KVEFEELLQT KTAGRLLEGL SLRDISLGNS LPVFKTAKLM
     KPVSLNEDGM PEELNFEVDL EYNGGFHLAI DVDLVFGKSA YLFVKMTRVV GRLKLQFTRV
     PFTHWSFTFL EDPLIDFEVK SQFEGRPLPQ LTSIIVNQLK RVIKKKHTLP NYKIRYKPFF
     PFQVQPPIGS SSCEFDLSIQ ASGLVEGRLR VTLVECSRLF ILGSYDRETY VHCTFELSSH
     EWKEKTRSSI KTTELIKGPS GSVGMTFRHV PASEGDAVHV SIETITPNSP AALADLQRGD
     RLIAIGGVNV TSSVQVPKLL KQAGERVLVL YERPLRHQNA TVGLGAQQDG LGHIEEPSFI
     PPQAGYEEDP APITTLADIS DSKDMDSEFE ELIVDPKPSS LSSSAEARED FLSVNQSPKR
     TVANLASKPL GSISPILNRK LNLAGLQSPA RPPPTPKPSP HKSAESGEGP QRPTVPPPPP
     PTRPPVPPRP QIKLTSACSE TQSLLEGSES LAMADKTPEK TQTYSGGING DKNSAVTTPV
     KQPEPKPVVK PPEPCEELPV APPAPNKQDL ARDKVSESSI NTRDSTEDQS TWESSEIMFR
     NRMAHWGHAS VVFEVESNHK YLNVALWCKD PFKLGSLLCL GHVSLKLEHI ALECLSTSSS
     EYQSTFRLEA PEPRASVSRT ALRSLSTHKG FNEKLCYGDV TLNFSYLADG DSDMCGGLSE
     LERKASVPDE ELREREHVSC IPREDLAYSG IQLVEVRHNF QDTQFQNPTW CEYCKKKVWT
     KAASQCMICS YVCHKKCQEK CLAEYPLCVA ATDRRSADPE AKSTINRATT GLSRHIINTG
     TRLLNLRQVP KSRLAEQAAD VVPDAVHTPD ISDNESSDTE TYTGASPSKH ATGGSNKLVR
     REGGLDDSVF IAVKEIGRDL YRGLPTDERS QKLELMLDKL QQEIDQELEH NNALVLEEKE
     TGDARRKALI ASALAKSGER LQALTLLMIH YRAGIEDLES VDSTSTSPSE PQGLKTKGVA
     LEEALLEPEV YDSDICNPVE AQQSEDITEE QICVEALH
//
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