ID A0A3P8YBC7_ESOLU Unreviewed; 406 AA.
AC A0A3P8YBC7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Potassium two pore domain channel subfamily K member 18 {ECO:0000313|Ensembl:ENSELUP00000013902.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000013902.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000013902.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000013902.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR RefSeq; XP_010890556.1; XM_010892254.2.
DR AlphaFoldDB; A0A3P8YBC7; -.
DR STRING; 8010.ENSELUP00000013902; -.
DR Ensembl; ENSELUT00000022559.2; ENSELUP00000013902.1; ENSELUG00000013969.2.
DR GeneID; 105023226; -.
DR KEGG; els:105023226; -.
DR GeneTree; ENSGT00940000165789; -.
DR InParanoid; A0A3P8YBC7; -.
DR OMA; ENTSCSH; -.
DR OrthoDB; 2903084at2759; -.
DR Proteomes; UP000265140; LG06.
DR Bgee; ENSELUG00000013969; Expressed in stomach and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF291; POTASSIUM CHANNEL SUBFAMILY K MEMBER 18; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..166
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 309..378
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
SQ SEQUENCE 406 AA; 46233 MW; AFFA0EA8F503A27C CRC64;
MSMAVGKPRV FVEKSKKCVS KLWKLFPHVF LILSLIGYAV FGAVLFSYIE GSSASTTERE
YHAFLGELVR EIQNYTGNSS SNFTQEQDLV KHLENEIPKR FKSIWLQRPD NWTFFGSLFF
CCTVFTTVGY GEIYPVTLSG KVACILYAML GIPLMLLVIT DVGDVLAVLL SRAYRRLHTF
ICTLPQSGRW SPSEDKVKPV DGGQDAIPEG SYTFSHEVVV QEPMDIRHVL QSQQSVKRKS
IQLHRNTEIF ERIIARENFC RLSPLVRSLS CPELDRMPPP PKDFAIWDFT GIGDNMDKLD
VPLLLLLVVV FSYILFGGLM LPLWEEFGTF DAYYFCFITL TTIGFGDIVP KHPKYFMLTF
FFIIMGMAIM SMAFKLGQSR IVCFYQQCMR CISGGKVELK DKLGSE
//
