ID A0A3P8YBH2_ESOLU Unreviewed; 856 AA.
AC A0A3P8YBH2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Lethal(3)malignant brain tumor-like protein 1 {ECO:0000313|Ensembl:ENSELUP00000013150.1};
GN Name=L3MBTL1 {ECO:0000313|Ensembl:ENSELUP00000013150.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000013150.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000013150.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000013150.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_010896038.1; XM_010897736.2.
DR AlphaFoldDB; A0A3P8YBH2; -.
DR STRING; 8010.ENSELUP00000013150; -.
DR Ensembl; ENSELUT00000021608.2; ENSELUP00000013150.1; ENSELUG00000013312.2.
DR GeneID; 105026340; -.
DR GeneTree; ENSGT00940000159708; -.
DR InParanoid; A0A3P8YBH2; -.
DR OMA; KVRPPHN; -.
DR OrthoDB; 2905251at2759; -.
DR Proteomes; UP000265140; LG12.
DR Bgee; ENSELUG00000013312; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20131; MBT_L3MBTL1_rpt1; 1.
DR CDD; cd20134; MBT_L3MBTL1_rpt2; 1.
DR CDD; cd20137; MBT_L3MBTL1_rpt3; 1.
DR CDD; cd09582; SAM_Scm-like-3MBT3_4; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 4.10.320.30; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047361; MBT_L3MBTL1_rpt1.
DR InterPro; IPR047362; MBT_L3MBTL1_rpt3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR12247:SF69; LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF01530; zf-C2HC; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF103637; CCHHC domain; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT REPEAT 300..400
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 408..507
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 516..611
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 787..851
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 93849 MW; C1891F7C2A8F06BC CRC64;
MSSKVEVDVS AKEEDPTSFT VSSDALSSND TLSRRTCPQT TTTLILPELG SLAPLGTAPA
PSAQNTEVSS TAVEGSNGAT AGEVETPTLA PQVGGTCSIV HVLEWKEGMA ILPSSNLKFC
VSDCGTLEMI SPGKISSAES AVVVSGKTSD SENRPANNTD VMSPLNSVGV VAPDQERPLK
IESKTQGGPG ALGGPGALGG PGGLGRPSQL KNCDPMAQRT YPEQLRREPM TDKRVGGAEK
IPGARLASLD PELLKPMKKR KRKDYMSPSE EESELDGMDY LKTEVRHNRA GAGEVKVEPW
TWAQYLEETK AVAAPAKLFH ESQRVPQCRS GFRQGMKLEG IDPQHPSMYF VLTVAEVCGF
RLRLHFDGYS DSHDFWVNAN CPDIHPAGWC ESTGHKLYTP RGCKEEEFSW ANYLRMSKAQ
VAPEEVFASP GRTDMQCGFE VGMKLEAVDR MNPSLICVAT VTDVVDDRFL VHFDNWDDTY
DYWCDASSPY IHPIGWCQER SLSLTPPQGY PDPGRFSWPR YLDETGSTAV SADSFKVRPA
HGFQAQMKLE AVDKRSPGLI RVATVEEVDT HRIKVHFDGW SHVYDEWMDS DNPDIHPVGW
CDSTGHPLKV PPCDSNKTPD LGPREPATTA QSSFPSMPCK GITNSRSNKY SFHHRKCPTP
GCDGSGHVTG RFTAHHCLSG CPLAERNQGR LKTDLSDTEG SGAKRNILVF GQRTKKSRYH
GRIGRPPKYR KSQQRTYQTM TTEGICPSLF MSALSGHPDR TLSLCWEQHC KLLPGVQGIH
ATQVAAWTVE EVFGFVQNLT GCEEQACVFK EEMIDGEAFL LLTQTDIVKI MSIKLGPALK
ISNAILMFKS TDEGLK
//
