ID A0A3P8YBX9_ESOLU Unreviewed; 1923 AA.
AC A0A3P8YBX9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRS {ECO:0000313|Ensembl:ENSELUP00000013611.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000013611.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000013611.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000013611.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSELUT00000022206.2; ENSELUP00000013611.2; ENSELUG00000013946.2.
DR GeneTree; ENSGT00940000153617; -.
DR Proteomes; UP000265140; LG08.
DR Bgee; ENSELUG00000013946; Expressed in embryo and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14627; R-PTP-S-2; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1923
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027805688"
FT TRANSMEM 1261..1284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..120
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 132..221
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 233..315
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 322..412
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 417..511
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 515..605
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 610..712
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 717..816
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 817..916
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 917..1012
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1016..1099
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1368..1623
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1543..1614
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1655..1914
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1832..1905
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 397..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1923 AA; 213865 MW; A0F08DEC5418A7F6 CRC64;
MAAEGPPCLS LPSLLLLSLL LTCCHALSPP RFTKVPVDQI GVSGGVVSFV CQATGDPKPR
VGWNKKGKKV NSQRIETIEF DEGAGAVLRI QPLRAPRDEN IYECVAENSE GEVNVNAKLS
IIREDLLPAG FPNIDMGPQL KVVERTRTAT MLCAASGNPD PEITWFKDFL PIDPNSSNGR
IKQLRSGALQ IENSEETDQG KYECVASNVE GVRYSSPANL YVRELREVRR VPPRFSIPPT
SHEIMPGGSV NITCVAVGSP MPYVKWMINS EDLTPEDEMP VGRNVLELNS VRESANYTCV
AMSSLGIIEA VAQITVKSLP KPPGAPLVTE TTATSVTITW DSGNPDPVSH YIIQYRAKSP
DSKFETVDGI TTTRYSIGGL YPNTEYEIRV SAFNTIGQGP PSDPVEARTG EQAPASPPRN
VQVRIISQTT MMVRWDEPEE PNGQIRGYRV YYTMDPSQPM NMWQISNVQD SIITTIKSLV
ASETYSVRVL AFTSVGDGPF SDPVHVKVLQ GVPGQPTKFQ VGAVSDTSIE LTWEPAYDKE
GIVSYELRYK EGNSGSQVTK TFNPTSAYVV EGLRANTEYH FSLAAISNKG IGAFTNDISQ
KTLQAKPSAP PQDIKCSSSS STALLVSWSP PPVESQNGAL AGYLVRYQVV GASVEGGGVG
EPMEEPAVPP SEGRLLLQKL EKWTQYRITL AAFTEIGPGP ESEPLLCRTD EDVPGAPPRR
VEVEVLNSTA IKVMWRSLLP GGQHGQIRGY QVHYVRVENG ESRGLPLIKD VMLADAQEMV
IGGLQPDTTY SITVAAYTTK GDGARSKPKL VVTKGAVPGP PYLSVAQDSE TSAMVRWDPP
DVLIQGVGLQ GYRLQFGRKD ISPLATLEFT PQERQYTVAN VHRGATYLFK VQAKSRGGFG
EEATAELQVP EHTPQGYPQI SESSNVTCCS VELAWSPPVL AERNGDITEY TLAYQEAGTT
GAPRELSLPA SQSSYVLSSL KPNSAYDVKI RAHTSVGPGP FSPPVQYRTV AYDTDVPKNF
TVKWVTKTTV LLTWKFAERR FPFRCTIEYN RQKMDVDARL TKALVTGLRP NTTYEFRISC
QDNTEGAPRH RVVARTAPPI LVKKPRLDLY SEPDNILTMG FAPVDGKDIK IFYVVVVPIK
KGSGTVRHLK NPDEMDLEEL LRDVTPKRRT RRQLGPADSR KPYITACFKQ LPASFTLGTD
HRQSSCENKP LEPGQEYVFF LLAELNTTAG KTFAASPYTD SVVTPETEGD PTPADNGGDG
LIWVVGPVLA VVFIICIVIA ILLYKNRKRK ESEPRTKCLL NNAEIAPPHP TDPVEMRRIN
FQTPDSGLSS PLSEADFDYE SMMNHPPIPI AELPEHTDLL KANDNLKLSQ EYESIDPGQQ
FTWEHSNLEV NKPKNRYANV IAYDHSRVIL TPIEGITGSD YINANYIDGY RKQNAYIATQ
GPLPETFGDF WRMVWEQRAA TVVMMTRLEE KSRIKCDQYW PSRGTETYGM TQVTLLDTIE
LATFCVRTFS LHKNGSSEKR EVRQFQFTAW PDHGVPEYPT PFLAFLRRVK TCNPPDAGPI
IAHCSAGVGR TGCFIVIDAM LERIKHEKTV DIYGHVTLMR SQRNYMVQTE DQYSFIHDAL
LEAVACGNTE VAARSLYSYI QKLAQVETGE HVTGMELEFK RLANSKAHTS RFISANLPCN
KFKNRLVNIM PYETTRVCLQ PIRGLEGSDY INASFIDGYR QQKAYIATQG PLAETTEDFW
RMLWENNSTI IVMLTKLREM GREKCHQYWP AERSARYQYF VVDPMAEYNM PQYILREFKV
TDARDGQSRT VRQFQFTDWP EQGVPKSGEG FIDFIGQVHK TKEQFGQDGP ISVHCSAGVG
RTGVFITLSI VLERMRYEGV VDIFQTVKML RTQRPAMVQT EDEYQFCYQA GLEYLGSFDH
YAT
//
