ID A0A3P8YCY1_ESOLU Unreviewed; 1927 AA.
AC A0A3P8YCY1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Myosin heavy chain, fast skeletal muscle-like {ECO:0000313|Ensembl:ENSELUP00000013971.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000013971.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000013971.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000013971.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 8010.ENSELUP00000013971; -.
DR Ensembl; ENSELUT00000022881.2; ENSELUP00000013971.2; ENSELUG00000014094.2.
DR GeneTree; ENSGT00940000163461; -.
DR Proteomes; UP000265140; LG06.
DR Bgee; ENSELUG00000014094; Expressed in bone element and 5 other cell types or tissues.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 5.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 82..773
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 650..672
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1172..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1896..1927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 175..182
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1927 AA; 220745 MW; C1D60E76B1C3D43D CRC64;
MSTDAEMQIY GKAAIYLRKP EKERMEAQTA PFDSKNSVYV ADVKELYLKG LVTARSEGKC
VVTPGKEFKE ADVYQMNPPK YDKIEDMAMM TYLNEASVLY NLKERYAAWM IYTYSGLFCA
TVNPYKWLPV YDMEVVNAYR GKKRMEAPPH IFSVSDNAFQ FMQIDQENQS VLITGESGAG
KTVNTKRVIQ YFATIAVSGV KKEAEPGKMQ GSLEDQIIAA NPLLEAYGNA KTVRNDNSSR
FGKFIRIHFQ GSKLAKADIE TYLLEKSRVS FQLPDERGYH IFFQMMTNHK PEIVEMALIT
TNPYDFPMCS QGQITVASIN DKEELDATDD AITILGFTND EKMSIYKLTG AVLHHGNLKF
KQKQREEQAE PDGTEVADKI GYLLGLNSAE MLKALCYPRV KVGNEYVTKG QTVPQVNNSV
SALAKSIYER MFLWMVIRIN EMLDTKNPRQ FYIGVLDIAG FEIFDYNSME QLCINFTNEK
LQQFFNHTMF VLEQEEYKKE GIVWAFIDFG MDLAACIELI EKPLGIFSIL EEECMFPKAS
DTSFKNKLYD QHLGKNKAFE KPKPAKGKAE AHFSLVHYAG TVDYNITGWL DKNKDPLNDS
VILLYGKSSV KLMATLYVAA PPEGKTRMKK GGKKKGGSMQ TVSSQFRENL GKLMTNLRST
HPHFVRCLIP NESKTPGLME NFLVIHQLRC NGVLEGIRIC RKGFPSRIIY ADFKQRYKVL
NASVIPEGQF MDNKKASEKL LGSIDVNHED YKFGHTKVFF KAGLLGVLEE MRDEKLASLV
GMVQALSRGF LMRREFTKMM ERREAVLTVQ YNIRSFMNVK TWPWMKVYFK IKPLLKSAET
EKELANMKEN YEKMQADLAK ALARKKELEE KMVAMVQEKN DLALQVASDS ENLNDAEERC
EGLIKSKIQL EAKLKETTER LEDEEEMNAE LTAKKRKLED ECSELKKDID DLELTLAKVE
KEKHATENKV KNLTEEMASV EESVAKLTKE KKALQEAHQQ TLDDLQAEED KVNTLTKAKT
KLEQQVDDLE GSLEQEKKLR MDLERSKRKL EGDLKLAQES IMDLENDKQQ SDEKIKKKEF
ETAQLLSKIE DEQSLGAQLQ KKIKELQARI EELEEEIEAE RAARAKVEKQ RADLSRELEE
ISERLEEAGG ATAAQIEMNK KREAEFQKLR RDLEESTLQH EATASALRKK QADSVAELGE
QIDNLQRVKQ KLEKEKSEYK MEIDDLSSNM ESVAKAKSNL EKMCRTLEDQ LSEIKTKNDE
NVRQVNDISG QRARLLTENG EFGRQLEEKE ALVSQLTRGK QAFTQQVEEL KRQIEEEVKA
KNALAHGVQS ARHDCDLLRE QFEEEQEAKA ELQRGMSKAN SEVAQWRTKY ETDAIQRTEE
LEESKKKLAQ RLQEAEEGIE ATNSKCASLE KTKQRLQGEV EDLMVDVERA NAMAANLDKK
QRNFDKVLAE WKQKFEEGQA ELEGAQKEAR SMSTELFKMK NSYEEALDHL ETLKRENKNL
QQEISDLTEQ IGETGKSIHE LEKAKKTVET EKSEIQTALE EAEGTLEHEE SKILRVQLEL
SQIKGEVDRK IAEKDEEMEQ IKRNSQRLLD SMQSTLDAEV RSRNDALRVK KKMEGDLNEM
EIQLSHANRQ AAEAQKQLRN VQGQLKDAQL HLDDAIRTAE DVKEQAAMVE RRNGLMVAEI
DELRVALEQT ERGRKVAETE LVDASERVGL LHSQNTSLLN SKKKLETDLV QVQGEVDDIV
QEARNAEEKA KKAITDAAMM AEELKKEQDT SSHLERMKKN LEVTVKDLQH RLDEAENLAM
KGGKKQLQKL ESRVRELETE VEGEQRRGVD AIKGVRKYER RVKELTYQTE EDKKNVARLQ
DLVDKLQLKV KAYKRQAEEA EEAANQHMSK FRKVQNELEE AEERADIAET QVNKLRAKTR
DGGKEEN
//