ID A0A3P8YF49_ESOLU Unreviewed; 1806 AA.
AC A0A3P8YF49;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho GTPase-activating protein 32 {ECO:0000313|Ensembl:ENSELUP00000015232.2};
GN Name=ARHGAP32 {ECO:0000313|Ensembl:ENSELUP00000015232.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000015232.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000015232.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000015232.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
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DR Ensembl; ENSELUT00000039254.2; ENSELUP00000015232.2; ENSELUG00000015466.2.
DR GeneTree; ENSGT00940000154313; -.
DR Proteomes; UP000265140; LG07.
DR Bgee; ENSELUG00000015466; Expressed in spleen and 15 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF13; RHO GTPASE-ACTIVATING PROTEIN 32; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 246..308
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 359..554
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 687..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1265..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1605..1716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1742..1778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1070
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1145
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1181
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1608..1625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1658..1699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1754..1778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1806 AA; 200047 MW; 1685E69FD9BC233F CRC64;
LNSLDCVVSV TKKYNNWITS SGTVHQGLRP GRHPEEDDIV PELARLVYPR ERPDWEETIS
AMARSAEVPE LNAEPLLRSC SSTASMKVKN IKKLSFTKGH FPKLAECAHF HYENVDFGTI
QLALADEQSE VTRNGFESKE LVYLVQIYCQ GRSWIVKRSY EDFRVLDKHL HLCIYDRRFS
QLPELPRVSS LKDRAEAVSQ MLMAYLSRFS AIADNKINCG PALTWMEVDN KGNHLLVHEE
SSINVPAIAA AHVIKRYTAQ AADELSFEVG DIVSVIDMPP KEDTTWWRGK HGFQVGFFPS
ECVELINDKV PQSVTNSVPK PVSKKHGKLI TFLRTFMKSR PTKQKLKQRG ILRERVFGCD
LGEHLLNSGH DVPQVLKSCT DFIEKHGVVD GMYRLSGIAS NIQKLRHEFD SEQIPDLTKD
VYIQDIHCVG SLCKLYFREL PNPLLTYQLY EKFSEAVSAA TDEERLIKIH DVIQQLPPPH
YRTLEFLMRH LSHLATFSYV TNMHSKNLAI VWAPNLLRSK QIESACFSGT AAFMEVRIQS
VVVEFILNHV DVLFSPKLSS LIREGAGHNS LSRPKSLLVS SPSTKLLTLE EAQARTQAQI
NSPVTADSKY IEVGEGPAAL QGKFHTVIQF PTERKRPPVK SKKSPVGSWR SFFNLGKSSS
MSKRKLQRNP SEPSELKTMA LAGGRGDTAT LRSAKSEESL TSLHNVEGES KVYRPRRPRS
SSDALSASFN GDLLDSHTRQ HCNAFEKLAQ GNSVGSTRDR AGSDEDEGPI CVPALISPPR
SSGEDVDLSP PDIGMASLDF DPMSFQCSLP DGSFSFPMGL SDAATGVAGQ GSAENNSAPV
SPSFLGKFTS PFLSPDLSPA MGKKAESKKM TCSVSFPDKT LQAVSPIKSK SAILAPLTIS
EPFAVEFPAK PTESHCVPQP SSPPTGLLRD SPPLMGSVLL RTGEPSLSEA FQMEMHSCLF
PLLFSCPQAP FLFSVLTLQC PSVFVPLPGA VASLDSPKAS PSVSLLHPPP PPKNAARMLA
LALAESAQQA SILTQRRPSK SQPPTPLSPV RPMEPSHSLD WPPPPPMHPH TSLEEGLQTG
AAQTPNQTPT TITPNLTPSS SPPPTITTDK QPSQSSSEQP QPAPHPQSKP QLQPHPKPQS
HPQPNARLAP APAESVERPW EAIKPIQPPT EPVPHHNAHG PPTPPVRSIE SKLATAALSH
TEAANPAIFH NILAEASMPE EALAHPPPPL RKTSNHQSAY LYHTKGDAAS LEPMGEDYYH
QRAIPTGQPS YHYRPDSVPP HHSYVSKSEP QIPYSARTDQ RYYTLAHPRS YHQTMKHRGP
PRAGEYISPS LGHRGQAYGP MEGGPVYPTI RRVHSLHVPS NVRSVPFQRA EVPPDNELFY
YQRPVYQCKA YQPPQQSPQA DYHVTQLQPY FENGRVQYRY SPYSPSTNPL DSPYYDVDPY
GTVRLRHFHS FGSRDLGPAL GRSGGKAGSY HYLSRHVFPP GKEHSFVSRD MPPVHGSKGA
AVYIAWDPDE SERLRMHSIR RESRARQKVK GPVMSQYDNV GMFVPGDLGR YETLHLRSKS
DPGKAMLMSA EGKDGHYGVH PGSQHAPRHL VSDLDLLMYM EPEKHCQGNG TGDQQISSRN
CPASHLHQAQ HLPRKQPHQQ DPSQHDPGDS ARGFQPSYER LDPDRHLNRA KTPGGHQKHD
DQQQPTPVKP ERLHSVRERP QQHYSQTPMP EPDRDYSYQL HGRQQRHSTV TVQSHYDNLD
DYHPAAVPQP QAPMPNSHGG SSGSFPTNPG FTGSHSNRAY STALGQGAFI PAELALQRPE
TEIHAE
//
