ID   A0A3P8YFP5_ESOLU        Unreviewed;       695 AA.
AC   A0A3P8YFP5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=DNA-binding protein RFX2 {ECO:0000256|ARBA:ARBA00039910};
DE   AltName: Full=Regulatory factor X 2 {ECO:0000256|ARBA:ARBA00042136};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000014720.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000014720.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000014720.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A3P8YFP5; -.
DR   STRING; 8010.ENSELUP00000014720; -.
DR   Ensembl; ENSELUT00000023619.2; ENSELUP00000014720.2; ENSELUG00000014877.2.
DR   GeneTree; ENSGT01050000244879; -.
DR   Proteomes; UP000265140; LG08.
DR   Bgee; ENSELUG00000014877; Expressed in nose and 15 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR007668; RFX1_trans_act.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619:SF17; DNA-BINDING PROTEIN RFX2; 1.
DR   PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR   Pfam; PF04589; RFX1_trans_act; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   4: Predicted;
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          177..252
FT                   /note="RFX-type winged-helix"
FT                   /evidence="ECO:0000259|PROSITE:PS51526"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   695 AA;  77333 MW;  45B9E24B8442FD1A CRC64;
     MQSSEGGSDS SSSVALRTST SAQAPVVQPV PASQQVQQIQ HVYPSQVQYV GEGGEAVYAN
     GTIRTAYSYS PDAQLYGQGS GATYFDSQSG GAQVTTVVSS ASGMPSHGMV GIAMDVGGSQ
     IISSGSTYLI HGGGMEGGRH HTSHSSRSSS AMLEMAIENL QKSEGIATHK SSLLNSHLQW
     LLDNYETAEG VSLPRSSLYN HYLRHCQEQK LDPVNAASFG KLIRSVFMGL RTRRLGTRGN
     SKYHYYGIRL KPDSPLNRLQ EDSQYMAMRQ QPVHQKQRFK PLQKVDGMGE SLSGGSQHSA
     STPEQSVAAQ SQHHQQYIDV SHVLPPFPSP DLGTQPLPER INMNDVKKLQ SLYRDHCEAT
     LDVVMNLQFH YIEKLWQTFW YSTAPSSDGT TTIPNSDEDM EGVIPREKLI ALCKYEPVKL
     WMRSCDHILY QALVEILIPD VLRPVPSTLT QAIRNFAKSL EGWLTTAMSD FPNEIVRTKA
     AVVSAFAQTL RRYTSLNHLA QAARAVLQNT SQINQMLSDL NRVDFANVQE QASWVCQCDE
     SVVQRLEQDF KVTLQQQSSL DQWAAWLDNV VNQVLKSHEG SPSFPKAARQ FLLKWSFYSS
     MVIRDLTLRS AASFGSFHLI RLLYDEYMFY LVEHRVAQAT GETPIAVMGE FSDLNSMMLM
     DKDDMSDMGS DEGRGPNEPA VKRERIEINH SLQEI
//