ID A0A3P8YGW4_ESOLU Unreviewed; 448 AA.
AC A0A3P8YGW4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Interferon regulatory factor 9 {ECO:0000313|Ensembl:ENSELUP00000015827.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000015827.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000015827.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000015827.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8YGW4; -.
DR Ensembl; ENSELUT00000025001.2; ENSELUP00000015827.2; ENSELUG00000027212.1.
DR GeneTree; ENSGT00940000166207; -.
DR InParanoid; A0A3P8YGW4; -.
DR OMA; VRILYQP; -.
DR Proteomes; UP000265140; LG21.
DR Bgee; ENSELUG00000027212; Expressed in stomach and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF26; INTERFERON REGULATORY FACTOR 9; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 9..116
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 135..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 50755 MW; DEE79A3652FBD4EA CRC64;
MAAGKIRSTR RLRCWLVDQI NSGRYRGLIW DDDDKTMFRI PWKHAGKQDF RSEEDGAIFK
AWAVFKGKLP DGSNADPASW KTRLRCALNK SPEFQEVNER SQLDISEPYK VYRLVPMSEQ
GDRIILFANR AKTRGRKRKS SDSDSNEEEE VKQMKEEVST SLPVTMVSLE FLGGKMIIRF
KQVIEIFGFM SAAFIFKSVS PTHFYQSSQE IEHSVLTILQ DQVDQPLVIL KNDGSQDSYN
VSVKYLGREV LKCVVMGSDV RIAYQPSLPV PPLPVTGRFP CIQLPEPPST LTSSPGIGPQ
LQALSTLLPF MEKGVMLTSI GTGVYAKRYC QGRIFWTGPH SATVGPHKMN RAVEPEKLFD
KEVFRMELDH FRSCGGDPPR CDITLCFGEE FSETEDPSSK LIITQITLPW AQQQVKEAEE
FRESMTYLRD FASQSGDVTI NLVPIPYP
//
