ID A0A3P8YHI3_ESOLU Unreviewed; 4640 AA.
AC A0A3P8YHI3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dynein cytoplasmic 1 heavy chain 1 {ECO:0000313|Ensembl:ENSELUP00000016052.2};
GN Name=DYNC1H1 {ECO:0000313|Ensembl:ENSELUP00000016052.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016052.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016052.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016052.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8010.ENSELUP00000016052; -.
DR Ensembl; ENSELUT00000025304.2; ENSELUP00000016052.2; ENSELUG00000015996.2.
DR GeneTree; ENSGT00940000156103; -.
DR Proteomes; UP000265140; LG15.
DR Bgee; ENSELUG00000015996; Expressed in embryo and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1897..2043
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2214..2365
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2585..2735
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2927..3093
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3203..3251
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3400..3497
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4640 AA; 532259 MW; 5E395754B0892858 CRC64;
MSDGGGGDDS SGTMEVSAAV QTVADAAVLQ KHIRKLVPLL LEDGGEAPAS LETALEEKSS
IEQMRKFLSD PQIHTILVER STLKEDVGDE GEEEKECISY NINIDIHYGL KSNSLAFIKR
TGVIDADKPI STQVRVLTLS EDSPYETLHS FISNAVAPFF KSYIRESGKA DRDGDKMAPS
VEKKIAELEM GLLHLQQNIE IPEISLIIHP IILNIAKACY ERGEKPKVTD FGDKVEDPTF
LNQLQSGVNR WIREIQKVTK LDRDPASGTA LQEISFWLNL ERALNRIQEK RESPEVLLTL
DILKHGKRFH ATVSFDTDTG LKQAVETVND YNPLMKDFPL NDLLSATELD KIRLALVAIF
THLRKIRNTK YPIQRALRLV EAISRDLSSQ LLKVLGTRKL MHVAYEEFEK VMVACFEVFQ
TWEDEYEKLQ VLLRDIVKRK REENLKMVWR LSPAHRKLQA RLDHMRRFRR QHEQLRAVIV
RVLRPQVSAV PQHAPGEVVE PTEMKVAEVL FDAADANAIE EVNLAYENVK EVDGLDVSKE
GMEAWEAAMK RYDERIDRVE TRITARLRDQ LGTAKNANEM FRIFSRFNAL FVRPHIRGAI
REYQTQLIQR VKDDIESLHD KFKVQYPQSQ SCKMSHVRDL PPVSGSIIWA KQIDRQLTAY
MKRVEDVLGK GWENHVEGLK LKQDGDSFRA KLNTQEIFDD WARKVQQRNL GVSGRIFTIE
SSRARGRTGN MLKLKVNFLP EIITLSKEVR NLKWLSFRVP LAIVNKAHQA NQLYPFAISL
IESVRTYERT CEKVEERNSI SLLVAGLKKE VQALVTEGIA LVWESYKLDP YVQRLAETVF
NFQEKVDDLL LIEEKIDLEV RSLETCMYEH KIFTEILNRV QKAVDDLNLH SYSNLPIWVN
KLDIEIERIL GVRLQAGLRA WTQVLRGQME DKADVDMDTE APQVSHKPGG EPKIKNVVHE
LRITNQVIYL NPPIEDCRYK LYQEMFAWKM VILSLPRIQS QRYQVGVHYE LSEEEKFYRN
ALTRMPDGPA ALEEAYNSVK DNVNEVEQYV KVWLQYQCLW DMQAENIYNR LGEDLTKWQA
LLVQIRKARG TFDNAETKKE FGPVVIDYGK VQSKVNLKYD SWHKEVLSRF GQMLGNNMQD
FHSQISKSRQ ELEQHSVDTA STSDAVTFIT YVQTLKRKIK QFEKNVDLFR NGQRLLEKQR
FQFPPSWLYI DNIEGEWGAF SDIMKRKDTA IQQQVANLQM KIVQEDRAVE GRTIDLLADW
EKTKPVAGAL RPEEALQSLT IYEGKFSRLK DDRDKCSRAK EALELTDTGL LSGSEERVQV
ALEELQDLKG VWSELSKVWE QIDQAKEQPW VSVQPRKLRQ SLDGLLNQLK NFPARLRQYA
SYEYVQRLLK GYMKVNMLVI ELKSEALKDR HWKQLMKRLH VNWVLSELTL GQIWDVDLQK
NEMVVKDVLL VAQGEMALEE FLKQIREVWN AYELDLINYQ NKCRLIRGWD DLFNKVKEHI
NSVSAMKLSP YYKVFEEDAL SWEDKLNRIM ALFDVWIDVQ RRWVYLEGIF TGSADIKHLL
PVETQRFSSI STEFLALMKK VTKSPLVMDV LNIQGVQRSL ERLADLLGKI QKALGEYLER
ERSSFPRFYF VGDEDLLEII GNSKNVAKLQ KHFKKMFAGV SSILLNEENT VVLGISSREG
EEVLYKTPVD LLEHPKINDW LTLVEKEMRV TLAKLLAESV TEVGSFNKGN TIDLSKYIDW
IDRYQAQLVV LSAQIDWSEK VDAALTTISG GGDMSPLSSV LTNVEATLNV LADTVLMEQP
PLRRRKLEHL ITELVHQRDV TRQLIKNKVD NPKSFEWLSQ MRFYFDPKQT DVLQQLSIQM
ANAKFNYGFE YLGVQDKLVQ TPLTDRCYLT MTQALEARFG GAPFGPAGTG KTESVKALGH
QLGRFVLVFN CDETFDFQAM GRIFVGLCQV GAWGCFDEFN RLEERMLSAV SQQVQFIQVA
LREHSNPNRD RSAPVTCELL NKQVKVSPDM AIFITMNPGY AGRSNLPDNL KKLFRSLAMT
KPDRQLIAQV MLYSQGFRTA EILAKKIVPF FKLCDEQLSS QSHYDFGLRA LKSVLVSAGN
VKRERIQKIK RDKRERGENV DENEIAENLP EQEILIQSVC ETMVPKLVAE DIPLLFSLLS
DVFPGVQYMR GEMTALREEL RKVCAEMFLT YGDGDDVGSM WVEKVLQLYQ ITQINHGLMM
VGPSGSGKTM AWRVLLKALE RLEGTEGVAH IIDPKAISKD HLYGTLDPNT REWTDGLFTH
VLRKIIDNVR GELQKRQWII FDGDVDPEWV ENLNSVLDDN KLLTLPNGER LSLPPNVRIM
FEVQDLKYAT LATVSRCGMV WFSEDVLSTD MIFNHFLARL RSIPLDEGED EAFRIHKTTE
DEGEETASPM LQIQRDAASI LQPYFTSTGL VIKALEHASK MEHIMDFTRL RCLGSLFSML
HQACRNVALY NNNHSDFPMP IDQLERYMQR YLIYAVLWSF SGDGRLKIRG ELGEYIRRIT
TVPLPSAPNV PIIDYEVNIS GEWQSWQGKV PQIEVETHKV ASPDVVVPTL DTVRHEALLY
TWLAEHKPLV LCGPPGSGKT MTLFSALRAL PDMEVVGLNF SSATTPELLL KTFDHYCEYR
RTPNGVVLAP VQLGKWLVLF CDEINLPDMD KYGTQRVITF LRQMVEHGGF YRTSDQTWVK
LERIQFVGAC NPPTDPGRKP LTHRFLRHVP VVYVDYPGPA SLTQIYGTFN RAMLRLIPSL
RTFAEPLTAA MVEFYTMSQE RFTQDTQPHY IYSPREMSRW VRGIFEALRP LETLPVEGLI
RIWAHEALRL FQDRLVEDEE RRWTDENIDM VALKHFPNID REKALNRPIL YSNWLSKDYI
PVEQEELRDY VKARLRVFYE EELDVPLVLF NEVLDHVLRI DRIFRQPQGH LLLIGVSGAG
KTTLSRFVAW MNGLSVYQIK VHRRYTGDDF DEDLRTVLRR SGCKNEKIAF IMDESNVLDS
GFLERMNTLL ANGEVPGLFE GDEYAALMTQ CKEGAQKEGM MLDTHEELYK WFTSQVIRNL
HVVFTMNPSS EGLKDRAATS PALFNRCVLN WFGDWSTEAL FQVGKEFTIK LDLEKPNYKV
PDYMPVVYDK LPQPPSHREA IVNGCVFVHQ TLHQANSRLS KRGGRTMAIT PRHYLDFINH
YADLFNEKRS ELEEQQMHLN VGLRKIKETV DQVEELRRDL RIKSQELEVK NAAANDKLKK
MVKDQQEAEK KKVMSQEIQE SVYRQQEKIK DKQLSVKEDL DKVEPAVIEA QNAVKSIKKQ
HLVEVRSMAN PPAAVKLALE SICLLLGEST TDWKQIRSII MRENFIPTIV NFSADEISES
IREKMKKNYM SNPNFNYEMV NRASLACGPM VKWAIAQLNY ADMLKRVEPL RNELQKLEDD
AMDNKSKAEE VEQMIRDLES SIARYKEEYA VLISEAQAIK ADLAAVEAKV NRSTALLKSL
SAESERWEKS SETFKNQMAT IAGDCLLSAA FIAYAGYFEQ QMRQNLFTAW SHHLQQANIQ
FRTDIARTEY LSNADERLRW QANSLPADDL CTENAIMLKR FNRYPLIIDP SGQATEFIMN
EYKDRKITRT SFLDDAFRKN LESALRFGNP LLVQDVESYD PILNPVLNRE VRRTGGRVLI
TLGDQDIDLS PSFVIFLSTR DPTVEFPPDL CSRVTFVNFT VTRSSLQSQC LNEVLKAERP
DVDEKRSDLL KLQGEFQVRL RQLEKSLLQA LNEVKGRILD DDTIITTLEN LKKEAAEVTR
KVEETDIVMA EVETVSQQYL SLSSACSSIY FTMEALNQMH FLYQYSLHFF LDIYHTVLYE
NANLKSISDH TQRLNVITKD LFQGAFNRVA RGMCNQDHIT FAMLLARINL KGINSEPSYD
AEFQHFLRGA EIVLKGTAVP KVKGLTTEQC EAMVILSRLP AFKDLVSKVE ADEQFFMWIE
SNSPELSVPY LWTEEKQSTA IGQAVHQLLL IQAFRPDRML AMAHIFVSKV LGDNFMAIIE
QPLDLGNIVE SEVKPSTPVL MCSVPGYDAS GLVRDLAAEQ NKHITSISIG SAEGFNKADR
DINTAVKSGR WVMLENVHLA PGWLMQLEKK LHSMQPHASF RLFLTMEINP KVPVNLLRAG
RIFVFEPPPG VKANMLRTFS SIPVARMCKA PNERARLYFL LAWFHAVIQE RLRYAPLGWS
KKYEFGESDL RSACDTMDTW LDDTAKGRQN ISPDKIPWAA LKTLMAQSIY GGRIDNDFDQ
RLLNTFLDRI FTTSSFDSEF KLAFKVDGHK DIKMPDGIRR EEFMHWVELL PDTQTPSWLG
LPSNAEMVLL TTQGTDMMGK MLKMQMLEDE DDLAYEKETK RERAAAAATT EAQPAWMRTL
LTTVWSVGHA HRRSPGSTGS HDPLFRFFER EVKMGSRMLQ DVRQDLSDVV MVCEGKKKQT
NNLRTLINDL VKGILPRSWC RYTVPTSMTV IQWVADFSER IKQLQAISQG ATAGGAKELK
NIHVCLGSLF VPEAYITATR QYVAQANSWS LEELCLEVNV TSTQGASLDA CSFGIKGLKL
QGATHGNNKL SLSNDISTEL PLTQLRWVKQ LSAEKKHMVT LPVYLNFTRA DLIFTVDFDI
APKEDPHNFY ERGVAVLCTE
//