ID A0A3P8YHM5_ESOLU Unreviewed; 403 AA.
AC A0A3P8YHM5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Parvin alpha {ECO:0000313|Ensembl:ENSELUP00000015445.2};
GN Name=PARVA {ECO:0000313|Ensembl:ENSELUP00000015445.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000015445.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000015445.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000015445.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the parvin family.
CC {ECO:0000256|ARBA:ARBA00005666}.
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DR AlphaFoldDB; A0A3P8YHM5; -.
DR STRING; 8010.ENSELUP00000015445; -.
DR Ensembl; ENSELUT00000024517.2; ENSELUP00000015445.2; ENSELUG00000015410.2.
DR GeneTree; ENSGT00950000183194; -.
DR InParanoid; A0A3P8YHM5; -.
DR OMA; TELESQX; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000015410; Expressed in spleen and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd21337; CH_PARVA_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR028433; Parvin.
DR PANTHER; PTHR12114:SF6; ALPHA-PARVIN; 1.
DR PANTHER; PTHR12114; PARVIN; 1.
DR Pfam; PF00307; CH; 2.
DR PIRSF; PIRSF039131; Parvin; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 2.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 325..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..233
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 293..400
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 26..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 45747 MW; 2D149CC54C8DC3ED CRC64;
HKYSPLFPFG QDNNKNRKLR SAAVAIPNKL KMASSPQKSP SSPKSPTPKS PPSRKKDDSF
LGKLGGTLAR RKKAKEVSEL QEEGMNAINL PLSPIPFELD PEDTMLEENE VRTMVDPNSR
NDPKLQELMK VLIDWINDVL VGERIIVKDL AEDLYDGQVL QKLFEKLEGE RLNVAEVTQS
EIAQKQKLQT VLEKINDTLK VSTRNIKWTI DSVHAKSIVA ILHLLVALSQ HFRAPIRLPD
HVSIQVVVVQ KREGILQSRQ VLEEITGNTE ALSGRHERDA FDTLFDHAPD KLNVVKKTLI
TFVNKHLNKL NLEVSELDTQ FADGVYLVLL MGLLEGYFVP LFNFFLTPEN FDQKVHNVAL
SFELMQDGGL EKPKPRTEDI VNCDLKSTLR VLYNLFTKYR NVE
//
