ID A0A3P8YHN5_ESOLU Unreviewed; 1012 AA.
AC A0A3P8YHN5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 12 member 3 {ECO:0000313|Ensembl:ENSELUP00000016043.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016043.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016043.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016043.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3P8YHN5; -.
DR STRING; 8010.ENSELUP00000016043; -.
DR Ensembl; ENSELUT00000025284.2; ENSELUP00000016043.2; ENSELUG00000015931.2.
DR GeneTree; ENSGT00940000155044; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000265140; LG19.
DR Bgee; ENSELUG00000015931; Expressed in mesonephros and 5 other cell types or tissues.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF9; SOLUTE CARRIER FAMILY 12 MEMBER 3; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 133..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..119
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 136..640
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 649..785
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 811..1011
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1012 AA; 111813 MW; E1476647AED848F9 CRC64;
MFSIALKQMV ELPVAPNEGI SLSAFRSPFS VSGKEGCKYS FDGSSYHYSD GNSMTSQRSS
QILTGFDTLD AAPNYDFYAN TNAPGRARRT RPSLFQLHSK IEVSTTPLAS RPTDVHSEEE
AEEPLSEPTR FGWVKGVMIR CMLNIWGVIL YLRLPWITAQ AGIGMTWVII LLSSCITGIT
GLSTSAIATN GKVKGGGTYF LISRSLGPEL GGSIGLIFAF ANAVAVAMHT VGFAETVQSL
MQESGTKMVD PTNDIRIIGV ITVTCLLAIS LAGMEWESKA QIVFFFVILV SFANYLVGTF
MPATPQKQAK GFFSYKVDIF VENFKPNYRG LEGSFFGMFS IFFPSATGIL AGANISGDLK
DPTVAIPRGT LMAIFWTTVS YIIIAGTIGG CVVRDASGGI NDTLSNNNDC LGPACKYGWD
FTACIKNTSC PFGLSNQYQT MSMVSGFAPL IAAGIFGATL SSALACLVSA PKVFQCLCKD
NLYPLIGFFG KGFGKNDEPI RGYVLTYIIA ICFILIAELN TIAPIISNFF LCSYALINFS
CFHASITNSP GWRPSFRFYS KWLALLGAVV SVIIMFLLTW WAALIAIGIV IFLLGYVLYK
KPSVNWGSSV QAGSYNMALS YCVGLNQVDE HIKNYRPQCL VLSGPPSCRP ALVDFVGTFT
KNLSLMMCAN VVTGEPSPSA LNASRNSSHV TWLNKRHIKS FYHGVVAKDL RTGVQMLLQG
AGLGRVRPNV LMMGFKRDWR RDTSSSIESY IGIIHDAFDL QYGLCVLRMK EGLDTSRSAQ
AHGKLTLGLR QAQRGMSTPL HPLPIFHPQP FTVFQSKQGK KTIDVYWLFD DGGLTLLIPY
LLKRKKRWAR CKVRIFVGGD IQRKEEQKTE VKDLISKFRL GFHDVEVLPD INARPQPEHV
KRFEDLIGPY RLNPDQKDCE DGQDNQNCPW MVSDEEIDRN KTKTLRQIRL NEVLQDYSRD
AAIIVVTMPV GRRGQCPSAL YMAWLETVSR DLRPPVLMVR GNQENVLTFY CQ
//
