ID A0A3P8YHW3_ESOLU Unreviewed; 650 AA.
AC A0A3P8YHW3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN Name=GLS {ECO:0000313|Ensembl:ENSELUP00000016118.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016118.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016118.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR RefSeq; XP_010889082.1; XM_010890780.3.
DR AlphaFoldDB; A0A3P8YHW3; -.
DR STRING; 8010.ENSELUP00000016118; -.
DR Ensembl; ENSELUT00000039637.2; ENSELUP00000016118.1; ENSELUG00000015999.2.
DR GeneID; 105022419; -.
DR KEGG; els:105022419; -.
DR GeneTree; ENSGT00390000010463; -.
DR InParanoid; A0A3P8YHW3; -.
DR OMA; RWGNRPI; -.
DR OrthoDB; 537490at2759; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000015999; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR HAMAP; MF_00313; Glutaminase; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF49; GLUTAMINASE KIDNEY ISOFORM, MITOCHONDRIAL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 123..205
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
FT REPEAT 568..590
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 629..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 72435 MW; 4421D434C03E1EAD CRC64;
MLQFRFSTVL KEFFQSNLKR SLAGISRNKT SLPIYYCFST ASVDVKVSSK LKVLHAGVHC
PLLYTTTGIR TYCTKAEGAA IPVTENAVPL TAVLLPDQVK KDETVKEAAT EKKRKAGILP
SLEDLLFYTI AEGQEKIPVH KFLTALKATG LRTGDPRLKE CMDTLKVTLK NTSDGVMLDR
HLFKKCVQSN IVLLTQAFRK KFVIPDFQSF TSHIDELYES AKKLNEGQVA DYIPQLAKFS
PELWAVSLCT VDGQRHTVGD TKVPFCLQSC VKPLKYAIAV HDHGTEYVHR FIGKEPSGLR
FNKLFLDEDD KPHNPMVNAG AIVCTSLIKQ GASNAAKFDY VMNFLNKMAG NEYVGFSNAT
FQSERESGDR NFAIGYYLKE KKCFPEGTDM TSILDFYFQL CSIEVTCESA SVMAATLANG
GFCPITGERV LSPEAVRDTL SLMHSCGMYD FSGQFAFHVG LPAKSGVSGG ILLVVPNVMG
IMCWSPPLDK LGNSVRGIQF CTDLVSLFNF HNYDNLRHFA KKHDPRREGG DQRVKSVINL
LFAAYTGDVS ALRRFALSSM DMEQRDYDSR TALHVAAAEG HAEVVRFLLE ACKVNPDPKD
RWGNTPMEEA LHFGHHDVVT ILQDYHNKYN PQEAPKKSKE TVEENLDGML
//
