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Database: UniProt
Entry: A0A3P8YIE2_ESOLU
LinkDB: A0A3P8YIE2_ESOLU
Original site: A0A3P8YIE2_ESOLU 
ID   A0A3P8YIE2_ESOLU        Unreviewed;       439 AA.
AC   A0A3P8YIE2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE            Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE            Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE   AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000015891.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000015891.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000015891.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC       Nucleus {ECO:0000256|RuleBase:RU361195}.
CC   -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC       {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR   AlphaFoldDB; A0A3P8YIE2; -.
DR   Ensembl; ENSELUT00000025105.2; ENSELUP00000015891.2; ENSELUG00000023358.2.
DR   GeneTree; ENSGT00940000157435; -.
DR   Proteomes; UP000265140; LG14.
DR   Bgee; ENSELUG00000023358; Expressed in testis and 14 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
DR   CDD; cd10492; MH1_SMAD_4; 1.
DR   CDD; cd10498; MH2_SMAD_4; 1.
DR   Gene3D; 2.60.200.10; -; 1.
DR   Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR   InterPro; IPR013790; Dwarfin.
DR   InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR   InterPro; IPR013019; MAD_homology_MH1.
DR   InterPro; IPR017855; SMAD-like_dom_sf.
DR   InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR036578; SMAD_MH1_sf.
DR   PANTHER; PTHR13703:SF45; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR   PANTHER; PTHR13703; SMAD; 1.
DR   Pfam; PF03165; MH1; 1.
DR   Pfam; PF03166; MH2; 1.
DR   SMART; SM00523; DWA; 1.
DR   SMART; SM00524; DWB; 1.
DR   SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS51075; MH1; 1.
DR   PROSITE; PS51076; MH2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU361195};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          18..142
FT                   /note="MH1"
FT                   /evidence="ECO:0000259|PROSITE:PS51075"
FT   DOMAIN          210..439
FT                   /note="MH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51076"
FT   REGION          161..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          37..64
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        167..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   439 AA;  48295 MW;  77EBCC9846E4B2E8 CRC64;
     LSKMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA
     ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQFAFD
     LKADNVCVNP YHYERVVSPG IDLSGLTLSS TLMVKDEYEF ENQPSHSGAD GHHQTIQHQP
     SRPGGPQESV IVLLSDATSG WPRNGTPDYW CSIAYFEMDV QVGETFKVPA SCPTVTVDGY
     VDPSGGDRFC LGQLSNVHRT EAIERARLHI GKGVQLECKG EGDVWVRCLS DHAVFVQSYY
     LDREAGRAPG DAVHKIYPSA YIKVFDLRQC HRQMQQQAAT AQAAAAAQAA AVAGNIPGPG
     SVGGIAPAIS LSAAAGIGVD DLRRLCILRM SFVKGWGPDY PRQSIKETPC WIEIHLHRAL
     QLLDEVLHTM PIADPQPLD
//
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