ID A0A3P8YJ79_ESOLU Unreviewed; 957 AA.
AC A0A3P8YJ79;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=NLR family CARD domain-containing protein 3 {ECO:0000313|Ensembl:ENSELUP00000016634.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016634.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016634.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016634.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR RefSeq; XP_010866134.1; XM_010867832.2.
DR AlphaFoldDB; A0A3P8YJ79; -.
DR STRING; 8010.ENSELUP00000016634; -.
DR Ensembl; ENSELUT00000026027.2; ENSELUP00000016634.2; ENSELUG00000016406.2.
DR GeneID; 105008513; -.
DR KEGG; els:105008513; -.
DR GeneTree; ENSGT01100000263573; -.
DR InParanoid; A0A3P8YJ79; -.
DR OMA; QALDFWC; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000265140; LG20.
DR Bgee; ENSELUG00000016406; Expressed in digestive tract and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 244..377
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 957 AA; 109372 MW; 44BBAF111733AB48 CRC64;
MSSAAQQLLR SQRDVLLVWT CEHPTPLLRR LRDAGVLSHV HYLSLLECSS SNAVAQALET
VCATEESSRG FLQVLKEVQD YYCDELQVWV ERHCSKREEG RQKVTAVKVK ENSKSLISKL
FKGKRKFSVS PEVKVEDLQN VLQKPWQSVK SSHLRTHKNT LLERTERLTS YAEGGRQVFN
SASHIEIRYT DLFVTEDNES FDNSQHEYFT LASRRARIYA HQACQRIHPC SLLSPQGPTG
CRPKRVKVKG IAGIGKSVIV QRLVYEWALG KHMREFTCIF DLRFRELNII KDALSLLDLL
GDRFRYFKTV LKDLLASPGS LLFILDGLDE FKYQLDWNTT DRDIDVDSKV SISELMMALI
KGSLLPESSV ILTSRPSTDA PKRFFQRCCM VLGFEEDQLK EYIIKFYKDH KVSGRVYDYI
LGNDNLFVLS FIPLYCYIIC TALAEFFSIE NQAEDESQSL EQNPPTTVSE VYYCYLFTAA
KHHALKGKAE RNTPRSEVLS LVRQQLINLG RLAYEKLLKS KIMFERQDME HYGLAPEDIE
NTFLSQMLVP LKENTVQMFS FFHLTVQEHL AALYCAINLS KQEDIIQALD LWCFGEIPPP
STSLSPLLSH DLHLGKTRVE NLQMFTRFFM GILRTRIGGQ LNGLMLAPLE VDVKEEDLPT
RLGLWFQAQF KERKLANQTA LNLLHCLMEL HMEAATSRAA SEIKRLNLFK IKLRVVDCAA
LHYVLQFSPH KLTELNLGYS DIGNRGLNRL APILHRCESL YLRYNRLDRE AATLESAVLK
SNKCQVKKLF MCGNNLGPDG VLELWKALEQ NTTLEELYLD ITGITERGTE NMVDSLSKNT
SLKTLTMVGN DIGEVGKRRL RELKCRRPEL CIIGNFVDDQ GLLQAYLDWV EEIRADQDQM
DSVKNADALH SILKGLRVES GGERKEGCKE DNTTKALELE TKILELLNCP AHLAGVR
//
