ID A0A3P8YJA4_ESOLU Unreviewed; 2030 AA.
AC A0A3P8YJA4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Dedicator of cytokinesis 10 {ECO:0000313|Ensembl:ENSELUP00000016015.2};
GN Name=DOCK10 {ECO:0000313|Ensembl:ENSELUP00000016015.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016015.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016015.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016015.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 8010.ENSELUP00000016015; -.
DR Ensembl; ENSELUT00000039591.2; ENSELUP00000016015.2; ENSELUG00000015930.2.
DR GeneTree; ENSGT00940000157469; -.
DR Proteomes; UP000265140; LG01.
DR Bgee; ENSELUG00000015930; Expressed in spleen and 15 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 2.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 147..256
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 630..807
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1577..2024
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 117..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2030 AA; 230270 MW; 6637FF881750233A CRC64;
MAAESTRRFT KNLLKPGSAA EIRQTASNAV RHSQEKPKLI DPLDYEAVIG DLGEELKEDP
LRDLLLFPDN DFTVCSCRYY NSPLHVVHFR YEEYSGDYRL LPRSLYKAEK LPSHSFEIDH
EDVDKDEDTT SLSSSKGGGG GGGGGIGVFR SGWLYKGNFN STVNNSITVR SFKRRYFQLT
QLTDNSYIMN FYKDEKISKE PKGCIFLDSC TGVVQNNRLR KHAFELKMNE VTYFVLAAES
EQDMEEWIST LTRILQISPH DGPSAPTHNG LLMLYSVFCL WGCLFLFQYI SETEEGVRLA
RREERLNLFS LDPDTPVLRS PRGEYPGGGG PTVHPFEEKL GRRLMITCRS LNLTLQGCVN
ETETGPVTNI EPFFVTVALL DVREGRKVSA DFHVDLNHEA VRQMLAGAGA GGHGLGQENG
QSSPAERRPG DCHLSPDLDA WLRFPQQAIL SVTNPHTDIV LVARVEKVLM GNIAVGTEPY
IKNTDSSKTV QKMLKSNKQF CSKLGRYRMP FAWSIRSVFK DNQGTVDRES RFSPLFKQES
SKISTEDLIK LVSEYRRAEK TSKLQTIPGT LDITVDCVPM EHPSKSNNCV TSSYVPVRPF
EGCGQHQVTV EVEEFVQDST KFTQPYRVYK NHIYVYPRHL KYDSQKSFAK ARNIAVYVEF
RSSDDEVAKP LKCIYSKPDG PVFTTAACSS VLHHSQNPDF YDEVKIELPI QLHEKHHLLF
SFYHVTCDIN AKTNAKKKEA LETPVGYSWL PLLREGRLAS QEFSIPVSCT LPPGYLLIKE
PGSTKNGSDL KWVDGGKAIF KVSTNVVSTV YTQDPHLNRF FQQCQKREMD LSQPPTSNFL
NCLKGLLSME KIPVIIRFLP VLFNQLFKVA ALVVCGQFVF KAESHGFRTV HEELAKGMTS
DLKSNEQATI RNILRFSWFF FELIVKSMAQ DLVDSDKIKL PRSQRFPSTY LGRLESLVMT
VSDHIFWKNK ELAEETRSAN LAVAAFVKRC FTLMDRGFTF KLISSYVNMI TATDNKVLCE
FKFEFLREVC NHEHYIPLSL PLPSAPVPPP PLSLSPPPVD MPEYSLTGEF CRKHFLTGLL
LRELGLALQD EQDLRHLALA CLKNLMAKHS LDSRYEKQAR IASLYLPLYG LILDNMPRFF
LRDLFPIYFT SSDQGSRDDL SVGGGVVAQV PHVIRHGNSV DASFSKEVLN SITAFSTLAV
STGNHADSRG SLISIESNPS NGDRNSEKMD GCEKFARPQS LIGFGSRFDK LDQAETRSLL
MCFLHIMKTI SEEVMVSYWH RAVHQEISDF FNILEKLAAA VKLAQATQNN GTLKGSNHSS
HQGPSTRGTM PIIRAKNALT NPKLLQMMET DGNIPEGDHL SPTDIEANLS TEVALTVLDV
LGLFVQHHKK QLLQDEGQNL LMKKVFDTYL LFFQINQSTN TLKHVFAALR LFIQKFPSAF
FQGKADLYGC LCYEILKCCN HRSSSTQTEA SALLYFFMRK NFEFTKGKSI VRSHLQLIKA
VSQLIADAGI GGSRFQQSLA IINNFANGDA PLKNTSFSAE VKDLTKRIRT VLMATSQMKE
HEKDPEMLVD LQYSLANSYA STPELRRTWL ESMAKIHVRN GDLSEAAMCY IHISALIAES
LKRRGDPPVP PSLTSLILCD TSASFSMGWA AFLCITPNVK EEGAMKEDTG TQDTTYTEDT
LVEQLELCVD YLWKSERHEL IADINKPVIA VFEKRRDFKR LSELYYDIHR SYLKVTEVVN
SEKRLFGRYY RVAFYGLVSG FFEEEESKEF IYKEPKLTGL SEISQRLLKL YSDKFGADNV
KMIQDSNKVN PKDLDPKFAY IQVTYVVPYF DDKEQQEKRT DFERHHNIKR FVFETPFTLS
GKKHGDVEEQ CKRRTMLTTS SSFPYLKKRI QVVEQQSTEM NPIEVAIDEM SHKVSELNQL
CAMEEVDMIR LQLKLQGSVS VKVNAGPMAY ARAFLEEKNA KKYPDNQVKL LKEIFRQFAE
ACGQALDVNE RLIKEDQLEY QEEMRAHYRD MLTELSTVMN EQVCGNPQTH
//
