ID A0A3P8YJB0_ESOLU Unreviewed; 380 AA.
AC A0A3P8YJB0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Tyrosyl-DNA phosphodiesterase 2 {ECO:0000256|ARBA:ARBA00017870};
DE AltName: Full=5'-tyrosyl-DNA phosphodiesterase {ECO:0000256|ARBA:ARBA00031304};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016669.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016669.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}.
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DR RefSeq; XP_010866004.1; XM_010867702.3.
DR AlphaFoldDB; A0A3P8YJB0; -.
DR STRING; 8010.ENSELUP00000016669; -.
DR Ensembl; ENSELUT00000026111.2; ENSELUP00000016669.1; ENSELUG00000016449.2.
DR GeneID; 105008404; -.
DR KEGG; els:105008404; -.
DR GeneTree; ENSGT00390000014242; -.
DR InParanoid; A0A3P8YJB0; -.
DR OMA; AENDWDM; -.
DR OrthoDB; 276861at2759; -.
DR Proteomes; UP000265140; LG10.
DR Bgee; ENSELUG00000016449; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd09080; TDP2; 1.
DR CDD; cd14344; UBA_TYDP2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR15822; TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR15822:SF4; TYROSYL-DNA PHOSPHODIESTERASE 2; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF14555; UBA_4; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 133..369
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT REGION 63..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 42567 MW; 87CEE5F0EC490972 CRC64;
MANIPTSVTT LEETRTRLCE EFASLTGSDS AVAQCYLAEN DWEMERALNS FFEADMEAVF
EVEDSPEQNS SPPKVKRQKL DKPQTNEECI DLTNEEAACA SSARVTDSKS VEPRASSSGT
SSEDPDDSKL SLVSWNVDGL DTANLGDRAR GLCSYLALYT PDVVLLQELI EPYVQYLKKR
AVSYTIIEGG EEGYFTGLML KKSRVKLLKS EIVSFPSTQM MRNLLVAQVK FKEQDLCVMT
SHFESCKGQA EERMKQLRLV LKRMNEAPPN VTVIFGGDTN LRDTEVVKVG GLPHGVCDVW
ERLGKQEHCR YTWDTRANSN KSVPYVSRCR FDRIYLRPAK EGPGSQMAPD HMALLGLEKL
DCGRYTSDHW GIYCSFIPGS
//
