ID A0A3P8YJM6_ESOLU Unreviewed; 1030 AA.
AC A0A3P8YJM6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Aryl hydrocarbon receptor {ECO:0000256|ARBA:ARBA00015909};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016120.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016120.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016120.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_010889349.1; XM_010891047.2.
DR AlphaFoldDB; A0A3P8YJM6; -.
DR STRING; 8010.ENSELUP00000016120; -.
DR Ensembl; ENSELUT00000039636.2; ENSELUP00000016120.1; ENSELUG00000015980.2.
DR GeneID; 105022533; -.
DR KEGG; els:105022533; -.
DR GeneTree; ENSGT00940000154486; -.
DR InParanoid; A0A3P8YJM6; -.
DR OMA; MIRVEME; -.
DR OrthoDB; 5360131at2759; -.
DR Proteomes; UP000265140; LG22.
DR Bgee; ENSELUG00000015980; Expressed in liver and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:UniProt.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:1904613; P:cellular response to 2,3,7,8-tetrachlorodibenzodioxine; IEA:UniProt.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR CDD; cd11436; bHLH-PAS_AhR; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR039091; AHR/AHRR.
DR InterPro; IPR033348; AHR_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR PANTHER; PTHR10649:SF18; ARYL HYDROCARBON RECEPTOR 1B; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 27..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 121..184
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 111546 MW; C3DCB22EE9C3E9AE CRC64;
MYAGRKRRKP VQRGIEVKDQ NAKQAAPSEG TKSNPSKRHR DRLNSELDRL ASLLPFPEEV
TSSLDKLSIL RLSVSYLRTK NFFSVALKTH TYKGLTANGS SHDNSKETGL VDGWMPEGEL
LLQALNGFVL VIAAEGVIFY SSHTIQDYLG FHQTDVMHQS VFELIHAEDQ QEFRRNLHWA
LNPPAMPQPA EPPPDGEPVP SSSLVTYNPD HLPPENSSFL ERSFVCRFRC LLDNSSGFLA
LTLQGRLKFL HGQNRRLDDG CNVPPQLALF AIATPLQPPS ILEIRTKNMI FRTKHKLDFT
PMACDAKGKI VLGYTEAELR VRGSGYQFIH AADMLYCAEN HVRMIKTGES GLTVFRLLTK
ENRWKWVQAN ARLVYKNGKP DYIIATQRPL VEEEGGEHLR KRSMHLPFTY ATGEALLYQT
SYPIHGLTDT LQPKGKTRSK KGKLDKNSTK ESGGLDPSSL LGALMRQDES VYVCQPAVEP
KMSFHSSLFS DRGDGAGDGA GGYSGGPLGG DGGGDIHGGF SGGPLGGDGG GSWSAMPNGV
IANTAGPMGH PLSSFDPLLT TLDCLSLEGD ETCSNSELFS ALENLGLNAE DLELLLLDER
MIGVEMDPDY IPSLNDLLTN NEILSYIHDS LENRTEEGQV GDGHASTPRA PALTSVPAST
PTQCPDPLPG TGLIPDPSPH RQAAFAAPTS SPTPDHPTSA SPAPRATSPN RLSSHRPPKQ
APIVQLSQQM QQHLGSVKPV LTKYPWPPTT ADAPKPSQPD AVLRTESLSA AHNGHRVAQR
QPDELNRQPQ ALVDGETSPW QPQRRDNIPG PSRHQRQLPR VQCHVKQQAD GAVLNGVHFN
PGCQGYSFSH QVGLISRGVN GACSNGHMDA SSATTTDAVT CVDYAMGDAT SAGVDMNGVK
MGSVGLYQGR GGLTANSYHP ELHKQQQVSS AYFPSTPYSP LDHILGLTHP QHATPSPDAY
GIFNSPANQD AARGKMETGC IFNNTNVAYT GSRLLTNGDS QTASDGLLNP PDALQSLATL
PDTQTTGFYL
//
